What are the best mushrooms for chronic pain?

Chronic pain can be debilitating. Fortunately, mushrooms offer a natural solution.

Let’s explore the best mushrooms for chronic pain relief and how they work.

Which mushrooms help with chronic pain?

Is lion’s mane good for chronic pain?

Does Cordyceps Mushroom Help Pain?

Can reishi relieve chronic pain?

Is chaga good for chronic pain relief?

How to get mushrooms?

How much lion’s mane is in AdaptogenShroomsgranola?

Is there a mushroom that helps with pain?

Many mushrooms appear to relieve pain, with adaptogenic mushrooms being particularly beneficial. Adaptive mushrooms have been used in traditional medicine to treat various conditions, and research shows that many of them can help you deal with chronic pain.

The best mushrooms for chronic pain

Many mushrooms can help treat pain, even popular, readily available types such as shiitake mushrooms (Lentinus edodes) and white mushrooms (Agaricus blazei). The best types of mushrooms for chronic pain are:

  • Lion’s mane mushrooms (Hericium erinaceus)
  • Cordyceps mushrooms (Cordyceps militaris)
  • Reishi Mushrooms (Ganoderma lucidum)
  • Chaga mushrooms (Inonotus obliquus)

Lion’s mane mushrooms

Lion’s mane mushrooms (Hericium erinaceus) have positive effects on brain health, with benefits including preventing memory loss and improving cognitive function. But did you know that the many benefits of lion’s mane include relief from chronic pain?

Not only does this amazing functional mushroom promote nerve growth and recovery, but it also appears to relieve nerve pain. To learn more about this and other benefits of Hericium erinaceus, check out our guide to lion’s mane mushrooms.

Lion’s Mane: Best mushroom for nerve damage

Lion’s mane is one of the best mushrooms for nerve damage thanks to its ability to help nerve growth. Hericium erinaceus appears to promote nerve growth stimulating the production of nerve growth factor (NGF) proteins.

One in vitro study suggests that one of the properties of the lion’s mane mushroom is its ability to induce neurite outgrowth in PC12 cells. Active compounds extracted from Hericium erinaceus fruits significantly increased the presence of NGF proteins in these cells.

ONE study published by the International Journal of Medicinal Mushrooms examined the ability of lion’s mane to regenerate damaged nerves. In this study, mice given lion’s mane extract recovered significantly faster after peripheral nerve injury than their counterparts.

Lion’s Mane Mushrooms for Pain Management

Lion’s mane mushrooms appear to be useful in the treatment of neuropathic pain. ONE 2019 study examined the effect of Hericium erinaceus on cisplatin-induced peripheral neuropathy.

Cisplatin is a highly effective anticancer drug often used to treat solid tumors. Those who take it in high doses, however, often experience nerve pain. This limits the dose that cancer patients can receive, as well as the effectiveness of the drug.

In this study, half of the animals received both cisplatin and a warm aqueous extract of lion’s mane, while the other half received only cisplatin. Hericium erinaceus treatment significantly reduced cisplatin-induced neuropathy and weight loss in rats.

The neuropathy-relieving properties of lion’s mane require additional research, particularly in human subjects. If you suffer from neuropathic pain, there is no harm in including this mushroom in your diet as an alternative treatment.

Cordyceps mushrooms

Cordyceps mushrooms it appears to help treat cancer through apoptosis of cancer cells and provide increased energy levels, among many other potential benefits.

Although there is no research on the effects of this mushroom on chronic pain, anecdotal research and its proven benefits in preventing inflammation and the treatment is promising. The root cause of pain is inflammation. Thus, by providing anti-inflammatory properties, Cordyceps can help reduce chronic pain.

Cordycepin, one of the bioactive compounds found in Cordyceps mycelia, has been studied for its anti-inflammatory properties in study 2020. The findings reveal that cordycepin-containing ethanol extracts block the mechanisms that cause inflammation in chronic disorders such as rheumatoid arthritis and Crohn’s disease.

Cordyceps militaris

Reishi mushrooms

Reishi (Ganoderma lucidum) is among them the healthiest mushrooms you can eat. They seem to reduce inflammation as well as help relieve the pain associated with shingles.

Reishi mushroom for pain relief

ONE study published in The American Journal of Chinese Medicine looked at the effects of reishi mushrooms on pain caused by shingles. The soothing properties of this edible mushroom became apparent after a few days of intake. By day 10, participants no longer experienced pain and none of the participants developed chronic postherpetic neuralgia.

Reishi mushroom for inflammation

Reishi is one of the best mushrooms for inflammation. The polysaccharides present in this type of mushroom appear to regulate the production of inflammatory cytokines, at least in mice. 2017 study.

This fungus also appears to affect the composition of the gut microbiota, which could benefit the treatment of inflammatory bowel disease and other autoimmune digestive disorders.

Chaga mushrooms

Chaga mushrooms benefit your skin, hair and overall health by helping you manage oxidative stress. These mushrooms also have amazing anti-inflammatory and soothing properties.

ONE 2005 study examined the effects of chaga on pain and inflammation in vivo and in vitro. Inonotus obliquus extract relieved inflammation, swelling and pain in mice and rats by inhibiting NF-kB proteins, which are responsible for pain and inflammation associated with injury or infection.

Want to take medicinal mushrooms for chronic pain?

If you want to try medicinal mushrooms for chronic pain, combining the benefits of several fungi is your best bet.

Us functional mushroom granola contains lion’s mane, one of the best mushrooms for chronic pain, making it a great place to start your pain relief journey.

Granola is vegan, gluten-free, delicious and packed with nutrients. What more could you want from your morning bowl of cereal?

 AdaptogenShroomsSuperfood Granola

Frequently asked questions about mushrooms for chronic pain

How much lion’s mane is in AdaptogenShroomsgranola?

AdaptogenShroomsgranola uses high-quality lion’s mane mushroom extracts, made from whole medicinal mushrooms. Our double extraction method extracts both water-soluble beta-glucans and alcohol-soluble triterpenes. Our brewing process breaks down the indigestible chitin cell walls of the mushroom to extract far more of these compounds than conventional processes.

One serving of granola provides us with 250 mg of ultra-concentrated lion’s mane extract, which is eight times more concentrated than a regular lion’s mane mushroom supplement. So you’re getting as much potency as you would a 2000mg lion’s mane mushroom powder, all in a granola bowl.

What is the best mushroom for osteoarthritis?

Hericium erinaceus is the best mushroom for osteoarthritis. In 2022, one animal study examined the effects of lion’s mane on osteoarthritis in Sprague-Dawley rats. This study concluded that lion’s mane can significantly reduce osteoarthritis pain, at least in animals.

How do people deal with constant pain?

People use various strategies to manage their chronic pain, including pain medications, analgesic adaptogens, participating in physical therapy for pain management, and seeking emotional support from friends and family. Some people may also benefit from alternative treatment for pain, such as acupuncture or massage.

Conditions such as frozen shoulder and similar conditions, which can cause persistent pain and stiffness, may require a combination of treatments to manage symptoms and restore mobility.

What is the best mushroom for depression?

Lion’s mane is, by far, the best mushroom for depression. This mushroom appears to stabilize levels of dopamine, a neurotransmitter directly related to depression and other mood disorders. To learn more about the benefits of this mushroom for depression, see our article on the link between Hericium erinaceus, depression and dopamine.

Which mushroom is best for joint health?

Many mushrooms can help you maintain and improve joint health. For example, turkey tail mushrooms, royal trumpet mushrooms, lion’s mane mushrooms, and maitake mushrooms all help maintain bone and joint health. Therefore, it is best to combine multiple types of mushroom adaptogens for optimal joint health.

What is the best mushroom for arthritis and inflammation?

Many mushrooms contain anti-inflammatory properties that are beneficial for arthritis. However, there are two fungi that stand out when it comes to treating inflammatory processes associated with arthritis – Hericium erinaceus and Antrodia camphorata.

One animal study examined the effects of the camphor fungus (Antrodia camphorata) on pain and inflammation in mice. The results show that this mushroom helps relieve pain and inflammation and could be a powerful agent in the treatment of arthritis.

Research on lion’s mane shows that this mushroom is also extremely beneficial in the treatment of arthritis, as it appears to inhibit the production of pro-inflammatory cytokines that worsen arthritic pain and inflammation. To learn more about this benefit, read our in-depth article on lion’s mane and arthritis.

What is the best mushroom for autoimmune diseases?

When it comes to fighting autoimmune disease, lion’s mane is the best mushroom you can get.

Lion’s mane mushroom appears to preserve memory and brain function in people with Alzheimer’sas well as helping to treat diabetes, the most common autoimmune disease.

Lion’s mane is one of the best alternative remedies for diabetesas it can lower blood sugar levels and relieve diabetic neuropathy, a common symptom of this chronic disease.

What is the best mushroom for gut health?

Each adaptogenic mushroom has benefits for the health of the digestive system, thanks to its high fiber content. However, lion’s mane appears to be particularly beneficial for gut health.

In a 2017 study, researchers examined the effects of Hericium erinaceus on inflammatory bowel syndrome (IBS) in rats. The researchers found a significant improvement in clinical symptoms and histological results in IBS rats after two weeks of treatment.

To learn more about the effects of Hericium erinaceus on digestive health, read our in-depth article on lion’s mane and digestion.

Should I take psychedelic mushrooms for pain relief?

Recent clinical studies show promising results when it comes to microdosing psilocybin mushrooms for pain relief.

This type of mushroom, also known as magic mushrooms, are psychedelic drugs that cause highs when taken in high doses and appear to help alleviate many physical and mental health conditions, such as anxiety and depressive disorder, when taken in tiny doses. doses.

ONE study review examined the effects of psychedelic mushrooms on chronic pain. This review concluded that magic mushrooms helped reduce symptoms of cluster headaches as well as relieve limb pain in patients with missing limbs.

While taking magic mushrooms for pain looks promising. However, psychedelic mushrooms are not federally legal in the US, and microdosing can cause side effects, so be careful if you choose to apply psychedelic mushrooms to your chronic pain treatment.


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  2. Wong, KH (2012). Neuroregenerative potential of the lion’s mane mushroom, Hericium erinaceus (Bul.: Fr.) Pers. (Higher Basidiomycetes), in the Treatment of Peripheral Nerve Injury (Review). International Journal of Medicinal Mushrooms, 14(5), 427–446. https://doi.org/10.1615/intjmedmushr.v14.i5.10
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  8. Park, YM (2005). In vivo and in vitro anti-inflammatory and anti-irritant effects of the methanolic extract of Inonotus obliquus. Journal of Ethnopharmacology, 101(1–3), 120–128. https://doi.org/10.1016/j.jep.2005.04.003
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  10. Yang, S.Y. (2022). Hericium erinaceus Mycelium Ameliorates Osteoarthritis Progression in Vivo. Nutrients, 14(13), 2605. https://doi.org/10.3390/nu14132605
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