The lion’s mane appeared on new brain nerves

Bioactive compounds in lion’s mane mushrooms can stimulate neurogenesis (formation of new nerves) and enhance memory. Research has shown that lion’s mane significantly enhances neural development and memory. The mushroom can even repair damaged nerve cells.

Does the lion’s mane cross the blood-brain barrier?

Does lion’s mane enhance neurogenesis?

How does lion’s mane repair nerve damage?

Does Lion’s Mane Promote Nerve Growth?

Does lion’s mane help with brain fog?

What time of day should you get the lion’s mane?

How to get lion’s mane for neurogenesis?

We read dozens of clinical trials to gain a deeper understanding of the mechanisms behind lion’s mane’s neuroprotective and neurogenic properties.

Here’s what we found.

What are lion’s mane mushrooms?

Lion’s mane mushroom, Hericium erinaceus, yamabushitake. This basic traditional Chinese medicine has many names. Commonly found in Europe, North America and Asia, this medicinal mushroom has been used in ancient Chinese medicine for a long time.

The lion’s mane feeds on the remains of dead trees, more specifically the organic matter found in the bark of trees called detritus. Still, the adaptogenic mushroom it can also feed on living trees, in which case it kills the tree over the years it lives as a parasite on it.

Benefits of lion’s mane

Research on health benefits of lion’s mane indicates that the mushroom has significant potential to promote neurogenesis, improve cognitive performance, prevent and repair nerve damage, and alleviate dementia, symptoms of depression and anxiety, and neuropathic pain, among other neurological properties health.

Hericium erinaceus seems to help:

  • reducing symptoms of anxiety and depression, as well as symptoms of other mental health conditions, such as bipolar disorder
  • alleviating cognitive decline and improving cognitive function
  • protection against dementia and mild cognitive impairment
  • grant reduction of nerve pain
  • fight various forms of cancer
  • relieves chronic inflammation and inflammatory bowel disease through its anti-inflammatory effects
  • cancer cell apoptosis
  • improving immune health
  • repair of nervous system injuries
  • lowering blood sugar levels
  • reducing the symptoms of neurodegenerative diseases such as Alzheimer’s and Parkinson’s

Lion’s Mane Vitamins and Minerals

The lion’s mane mushroom contains many vitamins, including thiamin, biotin, niacin, folate and vitamin B6. It also contains important minerals for health, such as:

  • calcium
  • iron
  • phosphorous
  • zinc
  • potassium
  • magnesium
  • copper
  • selenium
  • manganese

Lion’s Mane Bioactive Compounds

In addition to vitamins and minerals, lion’s mane mushrooms contain active compounds such as:

  • polysaccharides
  • polypeptides
  • beta-glucoxlan
  • prebiotic fibers
  • digestive enzymes
  • Hericenones
  • hedgehogs

Does the lion’s mane cross the blood-brain barrier??

Yes, Lion’s mane compounds can cross the blood-brain barrier. The blood-brain barrier serves an important function, the screening of sensitive brain tissues from blood-borne toxins.

While protecting your brain from toxins, the blood-brain barrier also keeps out many beneficial substances.

However, ericenones and erinacins— bioactive compounds found in fruiting bodies of many functional mushrooms, including lion’s mane – can cross the blood-brain barrier very easily. These beneficial compounds stimulate nerve growth factors (NGF) which can provide many benefits, including protection against brain injury, nerve regeneration (neurogenesis) and myelination.

What is Neurogenesis?

Neurogenesis is the process by which new neurons or nerve cells are formed in the brain. It entails the growth, development and integration of these cells into existing neural networks. Neurons are the main working parts of the nervous system. They send and receive electrical and chemical signals to send and process information.

Neurogenesis occurs mainly during embryonic development, when the brain is just forming. Recent research, however, has shown that it can also occur in certain parts of the adult brain, although less frequently. The two main areas where adult neurogenesis occurs are the subgranular zone (SGZ) of the dentate gyrus in the hippocampus and the subventricular zone (SVZ) covering the lateral ventricles.

The hippocampus is involved in learning and memory, while the SVZ helps generate new cells in the olfactory bulb, which is responsible for the sense of smell. Adult neurogenesis is thought to play a role in how well you think, remember and control your mood.

Here is a breakdown of the ways in which neurogenesis occurs.

  1. Fetal neurogenesis. During embryonic nervous system development, neural stem cells (NSCs) differentiate into neurons and other cell types, such as astrocytes and oligodendrocytes. This forms various brain structures and neural networks that enable cognitive, motor and sensory functions.
  2. Adult hippocampal neurogenesis. Neural stem cells and progenitor cells in the dentate gyrus of the hippocampus give rise to new neurons that integrate into existing circuitry. This process is believed to aid learning and memory consolidation, as well as mood regulation. This is the type of neurogenesis that lion’s mane is thought to affect.
  3. Olfactory bulb neurogenesis. Neural stem cells in the SVZ give rise to new neurons, which migrate to the olfactory bulb and integrate into existing neuronal networks.
  4. Injury-induced neurogenesis. Following a brain injury or stroke, the brain may exhibit increased neurogenesis in an attempt to repair damaged neural tissue.

Lion’s Mane and Neurogenesis

Available Research on lion’s mane shows that the fungus has powerful neurotrophic properties.

A 2023 study from the University of Queensland Brain Institute found that “The lion’s mane mushroom had a significant impact on brain cell growth and improved memory formation,” confirming what previous studies had also indicated that these mushrooms boosted memory by enhancing nerve growth.

ONE Study 2021 examined the effects of four compounds found in Hericium erinaceus for brain health and the results show that the mushroom shows great potential in improving memory.

Hericium erinaceus promotes the formation of new neurons. This mechanism may be at the root of the medicinal mushroom’s mental health benefits. Neurogenesis, the process of forming new neurons in the brain, may have an antidepressant effect.

ONE study examined the effects of the neurogenesis properties of lion’s mane on depression in animals. The results show that Hericium erinaceus exerts an antidepressant effectas it reduces inflammation in the brain and promotes the formation of new nerve cells.

It is the Lion’s Mane Nootropic?

Nootropics are compounds that support the brain’s natural cognitive functions and protect the nervous system, and studies show that lion’s mane mushrooms are loaded with these helpful compounds.

ONE 2012 document examined the nootropic potential of amikenon, a compound found in Hericium erinaceus. Amikenones can cross the blood-brain barrier, meaning they can provide benefits to brain cells through the bloodstream.

Although more research is needed, anecdotal evidence suggests that this key traditional remedy may help treat sleep apnea and other sleep-related breathing disorders, as well as increase alertness and improve focus. In addition, there is strong evidence for amikenones restoration of cognitive function in mild cognitive impairment.

Can Lion’s Mane Reverse Brain Damage??

Brain cell damage can be caused by oxidative stress, inflammation, stroke, and various other factors. Several studies suggest this Lion’s mane mushrooms have the ability to help regenerate nerves and reverse injuries to the nervous system.

One animal study considered its implications Hericium erinaceus in brain injuries caused by ischemic stroke. The researchers gave rats that had suffered an ischemic stroke an aqueous extract Hericium erinaceus. The Brain damage significantly improved in rats given lion’s mane supplementcompared to those who did not.

Does Lion’s Mane Promote Nerve Growth??

Clinical studies indicate that one of the properties of lion’s mane mushroom is its ability to stimulate nerve growth factor proteins (NGF for short). These proteins help in the growth and proper development of nerve cells.

Lion’s mane promotes nerve regeneration in Animals

One in vitro study considered its implications Hericium erinaceus on NGF-induced neurite outgrowth. The study looked at the effects of erikenone K in particular and found that the compound stimulates the production of NGF proteins. In it’s turn, promotes neurite overgrowth (the fundamental process in neuronal differentiation).

Based on the above results, it seems that the mushroom Hericium erinaceus definitely promotes neurogenesisat least in animals.

Lion’s mane can promote nerve growth in humans

Human studies (such as this one on effects of Hericium erinaceus on mild cognitive impairment in Japanese adults) show promising results, but the body of evidence is not strong enough to say with certainty that lion’s mane promotes nerve regeneration in humans.

Lion’s Mane for Brain Fog

Brain fog is defined by a lack of clarity, forgetfulness, and an inability to focus when performing everyday tasks.

Although there is not much research on the use of lion’s mane for brain fog, its existing brain benefits, anecdotal research, and available scientific studies seem to confirm that this mushroom can relieve the symptoms of this condition. disease.

If you want to learn more about the effects of lion’s mane mushroom on brain development and brain boosting properties, check out our article on lion’s mane and the brain.

What is the main cause of brain fog?

There is no single main culprit responsible for causing brain fog. This condition can be caused by stress, overwork, lack of sleep, too much screen time, and even certain mental illnesses and chronic inflammatory conditions.

Beating Brain Fog with Lion’s Mane Mushrooms

Yes, both anecdotal and research-based evidence seems to suggest that lion’s mane can reduce brain fog. Lion’s mane supplements have been reported to be effective in treating brain fog caused by migrainesinsomnia and Lyme disease after just a few weeks of regular use.

A 2018 study published in the Journal of Medicinal Food examined the effects of water extracts of the medicinal mushroom Hericium erinaceus on depressive symptoms, including brain fog. The results show that the “smart mushroom” can improve brain fog through its neurotrophic effect on the brain and its anti-inflammatory properties.

What can we say definitively? Lion’s Mane and Neurogenesis

Here’s what we know so far about it Hericium erinaceus and nerve development:

  1. This edible mushroom improved brain cell growth and regeneration in animal studies and had beneficial effects on memory and brain fog in human research.
  2. Evidence from animal studies is strong in favor of lion’s mane promoting brain regeneration, including its ability to promote neuron formation and regeneration of damaged neurons in the brain.
  3. Human studies are minimal on the effects of lion’s mane and neurogenesis. Those that do exist indicate a positive correlation between eating lion’s mane and improved cognition (suggesting neurogenesis).
  4. More research involving humans is needed to say for sure that lion’s mane helps the human brain grow new nerve cells.
  5. Since there is no downside to eating lion’s mane – and given its relatively low cost and high availability – it might make sense to incorporateHericium erinaceus nutritional supplement to one’s diet as a complementary and alternative medicine for neurogenesis, based on existing evidence.

When to get the lion’s mane

While you can pick Lion’s Mane Mushrooms at any time of day, we recommend picking them in the morning or early afternoon. Taking lion’s mane later in the day can make you feel anxious, as the adaptogenic mushroom can act as a natural stimulant. Therefore, it is best to take the mushroom before starting your work day so that you can reap the mental clarity and benefits that lion’s mane offers.

Is it safe to take lion’s mane every day?

Taking lion’s mane mushrooms is completely safe, and it can be very beneficial to take them daily. Frequent use has a cumulative effect, meaning you will begin to notice the effects of the mushroom sooner. However, the dosage in lion’s mane extracts varies greatly depending on the strength, so be sure not to exceed the dosage recommended by the manufacturer.

How does a lion’s mane make you feel?

Lion’s mane has no psychoactive properties, so you won’t get high on this mushroom. However, you can expect to feel more alert, awake and focused. With regular use, you may even begin to see an improvement in your overall mood, especially if you’re dealing with milder symptoms of anxiety or depression.

I’m interested in Taking the lion’s mane for neurogenesis?

If you want to try lion’s mane for neurogenesis, it’s important to use a high-quality mushroom supplement that contains high levels of beneficial compounds. Us AdaptogenShroomsSuperfood Granola contains a super-concentrated extract of the fungus, meaning you’ll get 10-15 times the nutrient density you’d get in a mushroom powder – without the mushroom taste.

In addition to containing lion’s mane extract, our granola also has super concentrated cordyceps and chaga mushroom extracts, it’s vegan, gluten-free and made entirely from pure ingredients you can pronounce. Who knew your morning bowl of cereal could be so delicious?

Frequently asked questions about lion’s mane and neurogenesis

Does a lion’s mane make you smarter?

While it doesn’t necessarily make you smarter, one of the many benefits of lion’s mane mushrooms appears to be memory improvement. Although human studies on this effect of the medicinal mushroom are still rare, some animal studies show that lion’s mane can improve memory. For example, a 2019 study concluded that lion’s mane supplement significantly improved recognition memory in aged mice.

Does Lion’s Mane Lower Testosterone?

There are no studies to indicate that lion’s mane mushrooms reduce testosterone production. Conversely, one of the effects of adaptogenic mushrooms, including lion’s mane, is often increasing testosterone levels in the body. Taking lion’s mane may or may not improve your testosterone levels – but it certainly won’t lower your testosterone.

Can Lion’s Mane Prevent Dementia?

Research shows that the adaptogenic mushroom Hericium erinaceushas a positive effect on the mental functions of people with memory loss and dementia.

According to a Double-blind, placebo-controlled clinical trial 2020lion’s mane mushroom extract significantly improved overall cognitive function in people with early symptoms of Alzheimer’s disease.

If you want to learn more about the mechanisms behind the dementia-preventing properties of this mushroom, check out our detailed post at lion’s mane and Alzheimer’s.

Can Lion’s Mane Replace Adderall?

Hericium erinaceus can help treat ADHD. Lion’s mane mushrooms can help with memory and improve focus, and some people find that Lion’s mane mushrooms help them eliminate the need for Adderall. However, always consult your doctor or psychiatrist before making any medication changes. Alternatively, you can take lion’s mane in addition to Adderall, as the fungus will not affect the effects of the drug.

Does Lion’s Mane Increase Serotonin?

Although lion’s mane does not increase overall serotonin levels, research shows that the mushroom has the ability to stabilize blood levels of serotonin, as well as levels of other neurotransmitters such as dopamine.

Therefore, the medicinal mushroom may increase serotonin levels in people with naturally low levels of the neurotransmitter but not in people with normal levels. This can be quite helpful in reducing symptoms of anxiety and depression caused by neurotransmitter imbalances.

Can you take lion’s mane and reishi together?

Yes, you can take lion’s mane mushrooms with any other type of medicinal mushroom, including the reishi and shiitake mushroom varieties. When it comes to adaptogenic mushrooms, the whole is always greater than the sum of its parts, so the benefits of reishi mushrooms can only be enhanced by taking them with lion brand and vice versa.

Can you take Cordyceps and Lion’s Mane together?

Yes, you can take Cordyceps and Lion’s Mane together and get more benefits from both fungi that way, which is why we included both mushrooms, in addition to chaga, in our granola. AdaptogenShroomsgranola combines the cancer-fighting properties of Cordyceps with the nootropic effects of lion’s mane and the immune-boosting properties of chaga.

Is the lion’s mane thinner than blood?

Lion’s mane mushrooms are anticoagulant, meaning they reduce blood clotting. While the adaptogenic mushroom will not act as a blood thinner on its own, it can help with the blood thinning properties of certain medications. Therefore, if you are taking blood thinners, it is best to consult your doctor before you start taking lion’s mane supplements.


  1. Wong, KH (2009). Improvement of functional recovery after rodent peroneal nerve injury by the lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae). International Journal of Medicinal Mushrooms, 11(3), 225–236.
  2. Martínez‐Mármol, R. (2023). Hericerin derivatives activate a pan-neurotrophic pathway in central hippocampal neurons that converges on ERK1/2 signaling that enhances spatial memory. Journal of Neurochemistry.
  3. Ryu, SH (2021). Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus. Bioorganic & Medicinal Chemistry Letters, 31, 127714.
  4. Taupin P. (2006). Neurogenesis and the effect of antidepressants. Drug Target Information, 1, 13–17.
  5. Chong, PS (2021). Neurogenesis-dependent antidepressant activity of Hericium erinaceus in an animal model of depression. Chinese Medicine, 16(1).
  6. Inanaga, K. (2012). Amycenone, a nootropic found in Hericium erinaceum. Personalized Medicine Universe, 1(1), 13–17.
  7. Lee, KF (2014). Protective Effects of Hericium erinaceus Mycelium and Isolated Erinacin A against Ischemia-Injury-Induced Neuronal Cell Death Through Inhibition of iNOS/p38 MAPK and Nitrotyrosine. International Journal of Molecular Sciences, 15(9), 15073-15089.
  8. Zhang, CC (2015). Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-induced neurite outgrowth in PC12 cells. Bioorganic & Medicinal Chemistry Letters, 25(22), 5078–5082.
  9. Mori, K. (2009). Improving effects of Yamabushitake mushroom (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367-372.
  10. Ratto, D., Corana, F., Mannucci, B., Priori, EC, Cobelli, F., Roda, E., Ferrari, B., Occhinegro, A. (2019). Hericium erinaceus improves recognition memory and induces hippocampal and cerebellar neurogenesis in lean mice during aging. Nutrients, 11(4), 715.
  11. Li, IC (2020). Prevention of Early Alzheimer’s Disease by Erinacin A-Enriched Hericium erinaceus Mycelia A Pilot Double-Blind, Placebo-Controlled Study. Frontiers in Aging Neuroscience, 12.
  12. Ryu, S. (2018). Hericium erinaceus extract reduces anxiety and depressive-like behaviors by promoting hippocampal neurogenesis in the adult mouse brain. Journal of Medicinal Food, 21(2), 174–180.

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