The benefits of lion’s mane for bipolar disorder

Lion’s mane mushrooms may be a promising complementary treatment for bipolar disorder (BPD). BPD is a complex condition, and we would never claim that the mushroom is the ultimate solution—but the evidence is pretty compelling that lion’s mane can be a useful addition to a treatment protocol.

What is bipolar disorder?

Can lion’s mane help people with BPD?

Is lion’s mane good for the brain?

Is lion’s mane good for mental health?

What are the benefits of lion’s mane?

Can lion’s mane be harmful?

Want to get the lion’s mane for BPD?

How Much Lion’s Mane Should You Take for BPD?

How much lion’s mane is in AdaptogenShroomsgranola?

Join us as we explore the potential benefits of lion’s mane for people with bipolar disorder. And, to learn more about this amazing mushroom, read our guide to the lion’s mane.

What is a lion’s mane?

Lion’s mane mushrooms (Hericium erinaceus) are medicinal mushrooms commonly found in forested areas of northern Europe, northern Asia, and North America. This mushroom is considered one of the the healthiest mushrooms in the world because of the many advantages it provides. Learn more about the power of adaptogens by reading on our guide to adaptogenic mushrooms.

What is Bipolar Disorder?

Bipolar disorder, also known as manic-depressive illness, is a mental health condition characterized by extreme changes in mood, energy levels, and activity levels. People with bipolar disorder experience periods of intense emotional highs, known as mania or hypomania, and periods of deep sadness or depression. Here are some symptoms associated with bipolar disorder:

Manic Phase Symptoms

  • Increased energy and activity levels
  • Elevated or irritable mood
  • Reduced need for sleep
  • Grandiose or inflated self-esteem
  • Racing thoughts and fast talking
  • Impulsivity and risky behavior

Depressive phase symptoms

  • Persistent sadness or hopelessness
  • Loss of interest or pleasure in activities
  • Fatigue or loss of energy
  • Changes in appetite or weight
  • Difficulty concentrating or making decisions
  • Thoughts of death or suicide

Can Lion’s Mane Help Bipolar Disorder?

While scientific research on the direct effects of lion’s mane on bipolar disorder is limited, there is promising evidence for related conditions. Studies have shown lion’s mane’s ability to reduce anxiety and depression in both animals and humans.

Consider the following facts:

  • Depression and anxiety often accompany bipolar disorder as prominent symptoms.
  • Lion’s mane can improve depression and anxiety.
  • Lion’s mane has a positive impact on brain function.

Given these facts, we can assume that lion’s mane can help in the management of bipolar disorder. Although more research is needed to establish a direct link, the overlapping benefits for adjacent conditions provide a glimmer of hope for those seeking alternative approaches to support their well-being.

Certainly, there are no downsides to taking lion’s mane as a supplement. It’s affordable, safe and proven to offer a number of benefits.

What are the brain health benefits of Lion’s Mane?

Recent research suggests that lion’s mane could help grow new nerve cells through its effects on nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). ONE recent study found that the lion’s mane mushroom contains bioactive compounds that can promote nerve cell growth.

Other study on lion’s mane and hippocampal neurogenesis, published in 2023, found that “lion’s mane mushroom had a significant effect on brain cell development and improved memory formation” and added that a compound found in lion’s mane lion’s mane (Hericene A) “acts through a novel pan-neurotrophic signaling pathway, leading to improved cognitive performance”.

To learn more about this amazing benefit of lion’s mane, read our article on lion’s mane and neurogenesis.

What are the psychological effects of the lion’s mane?

Research shows that lion’s mane can relieve symptoms of anxiety and depressive disorders. Since bipolar disorder consists of depressive and manic episodes and is often accompanied by generalized anxiety, let’s take a look at how lion’s mane can help relieve depression, anxiety, and mania.

Lion’s mane depression study

ONE study published in Japan examined the effects of Hericium erinaceus on depressive symptoms in menopausal women. After taking a lion’s mane supplement for 4 weeks, these women reported feeling less depressed than at the start of the trial, suggesting that lion’s mane is effective in treating depressive symptoms.

Other scientific article on the therapeutic properties of lion’s mane for depressive disorders concluded that “H. erinaceus may be a potential alternative drug for the treatment of depression.”

If you want to know more about taking lion’s mane for depression, check out our article on the antidepressant effects of lion’s mane.

Stress study of the lion’s mane

Lion’s mane appears to reduce stress in both animals and humans. The effects of lion’s mane on anxiety were investigated in a recent clinical trial.

This trial examined the effects of lion’s mane on sleep quality and stress levels in female undergraduate students during a stressful exam period. Students reported feeling much calmer and their sleep patterns improved significantly after 4 weeks of using lion’s mane mushroom extract.

Other studyconducted on animals, concluded that “mice given H. erinaceus had…increased exploratory behavior toward novel objects,” which could indicate lower levels of anxiety in these animals.

To learn more about how to relieve stress with lion’s mane, check out our article on the benefits of lion’s mane mushrooms for anxiety.

Can Lion’s Mane help with mania?

There is currently no research on the therapeutic potential of Hericium erinaceus for mania associated with bipolar disorder. People with bipolar disorder anecdotally take this mushroom to reduce stress levels and relax during their manic episodes, which warrants scientific research into the benefits of lion’s mane for mania.

Benefits of lion’s mane mushroom

Lion's mane improves sleep quality

The lion’s mane mushroom offers a number of potential health benefits. This mushroom reduces inflammation, improves cognitive function, supports gut health, and relieves symptoms of many mental illnesses. Here are some key benefits associated with lion’s mane mushroom:

  • Lion’s mane contains dietary fiber that can support gut health by promoting the growth of beneficial gut bacteria and improving overall gut function.
  • Some studies suggest that lion’s mane improves sleep quality and may help regulate sleep patterns, potentially benefiting those with sleep disorders or insomnia.
  • Lion’s mane contains bioactive compounds that exhibit anti-inflammatory properties, which can help reduce inflammation in the body and support overall well-being.
  • Hericium erinaceus has been studied for its potential to prevent mild cognitive impairment and improve cognitive functions. It can improve memory, focus and mental clarity.
  • Studies show that lion’s mane can relieve symptoms of anxiety, depression and other mental health conditions.
  • The antioxidant activities of lion’s mane can help protect cells from oxidative stress caused by free radicals and reduce the risk of chronic diseases.
  • It slows the progression of many chronic diseases, such as multiple sclerosis, Parkinson’s disease and Alzheimer’s disease.

If you want to know more about the benefits of this wonderful mushroom, read our guide to the health benefits of lion’s mane.

Side effects of lion’s mane

There are no known side effects of lion’s mane. Centuries of use, anecdotal evidence, and available animal and human studies suggest that lion’s mane is completely safe for consumption. However, you may experience some mild digestive discomfort if you are new to this mushroom. Reading Our blog post on lion’s mane side effects For more information.

Interested in getting the lion’s mane for bipolar disorder?

Functional granola

IIf you want to get the lion’s mane for bipolar disorder, why not try our delicious medicinal mushroom granola? This mushroom product is vegan, gluten free, GMP free and contains high quality lion’s mane extract.

And, if you want to try more of our products, we also offer a tasty and nutrient-rich turkey tail powder you can check out.

How Much Lion’s Mane Should You Take for Bipolar Disorder?

The optimal dose of lion’s mane will vary from person to person. If you are taking lion’s mane for bipolar disorder, it is best to start with a low dose (500-1000 mg) and continue until you feel the effects. For more information on lion’s mane dosages, read our lion dosage guide.

How much lion’s mane is in AdaptogenShroomsGranola?

AdaptogenShroomsgranola uses high quality lion’s mane extracts from whole medicinal mushrooms. Our dual extract contains both water-soluble beta-glucans and alcohol-soluble triterpenes. Our decoction process breaks down the fruiting bodies and indigestible chitin cell walls of the mushroom to remove far more of these compounds than conventional processes.

One serving of granola provides us with 250 mg of ultra-concentrated lion’s mane mushroom extract, which is eight times more concentrated than regular lion’s mane supplements. So you’ll get as much power in lion’s mane as you would if you took a 2000mg lion’s mane mushroom powder, all in a bowl of granola.

Frequently asked questions about lion’s mane and bipolar disorder

Who should avoid the lion’s mane?

While no one should avoid lion’s mane completely, people with certain allergies or on certain medications should be careful when taking it.

If you are prone to allergies, especially to mold, yeast or other fungi, be careful when you start taking lion’s mane. Likewise, if you are taking blood clotting or diabetes medications, consult your doctor before taking this mushroom.

Visit our blog post on lion’s mane contraindications For more information.

Does lion’s mane lower dopamine?

Lion’s mane does not directly decrease or increase dopamine, but it does help regulate dopamine levels. ONE Animal study 2018 examined the mechanisms underlying the antidepressant effects of lion’s mane in mice.

The findings of this study suggest that when the mice were stressed, their dopamine levels dropped. Dopamine levels normalized after consuming lion’s mane, despite changes in stress levels, indicating that lion’s mane may be responsible for stabilizing dopamine levels.

Is lion’s mane good for ADHD?

While there isn’t much research on the benefits of lion’s mane for ADHD specifically, anecdotal evidence suggests that this mushroom could be an effective natural treatment for this condition. Some people even use lion’s mane as a natural alternative to Adderall. To learn more about this topic, visit Our blog post on the benefits of lion’s mane for ADHD.

Can lion’s mane replace antidepressants?

While lion’s mane may have mild antidepressant effects and can be used as a holistic health remedy for depression, it should not be used as a substitute for prescription treatments for depressive disorders. Never stop taking antidepressants without talking to a healthcare professional.

Does lion’s mane help mood?

Mood patients and medical examiners alike agree that lion’s mane can stabilize mood. This mushroom is an adaptogen, meaning it helps your body adapt to stress, both acute and chronic. So taking it will likely affect your mood in a positive way. Learn more about this topic at our spiritual benefits of the lion’s mane guide.

Does lion’s mane affect testosterone?

Lion’s mane can affect testosterone through its stabilizing benefits on hormone production. We take a deep dive into this topic Our blog post on lion’s mane and testosteroneas well as one for lion’s mane and DHT.

Does lion’s mane raise blood pressure?

There is no evidence to suggest that lion’s mane mushrooms raise blood pressure. In fact, studies show that lion’s mane can lower blood pressure in people with high blood pressure. ONE Study 2022 states that “bioactive peptides [found in Hericium erinaceus] have functional activities such as lowering blood pressure’.

Are there benefits for schizophrenia from lion’s mane?

While there is some preliminary research suggesting that lion’s mane mushroom may have potential benefits for cognitive function and mental health, more studies are needed to establish its effectiveness and safety in treating specific conditions, such as schizophrenia.

Lion’s mane contains bioactive compounds that may have neuroprotective and neuroregenerative properties, but should not be considered a substitute for standard medical treatment.

What is the ideal dose of lion’s mane depression?

There is no exact dose of lion’s mane mushroom that will relieve depression symptoms for everyone. However, you should try to get around 1000 mg per day or more if you are taking lion’s mane to relieve depression. If you are new to taking adaptogenic mushrooms, you may want to start with a lower dose and work your way up, as lion’s mane can upset the stomach if you are not used to taking it.

Does lion’s mane increase dopamine and serotonin?

Lion’s mane may have indirect benefits on dopamine and serotonin production through its hormone-regulating effects. While these benefits are promising, more research is needed to fully understand the effects of lion’s mane on serotonin levels in humans.

Is lion’s mane nootropic?

Yes, lion’s mane can be considered a nootropic. This mushroom provides a wealth of cognitive and mental health benefits. We’re taking a deep dive the nootropic benefits of lion’s mane in a recent blog post, check it out.

Can I get a lion’s mane with St. John’s Wort;

Yes, you can get the lion’s mane with St. John’s wort. Many naturopathic doctors recommend taking more than one adaptogen, as they all provide a unique set of benefits without interfering with the effects of other adaptogens.


  1. Lai, PL (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. International Journal of Medicinal Mushrooms, 15(6), 539–554.
  2. Martínez‐Mármol, R. (2023). Hericerin derivatives activate a pan-neurotrophic pathway in central hippocampal neurons that converges on ERK1/2 signaling that enhances spatial memory. Journal of Neurochemistry.
  3. Nagano, M. (2010). Reduction of depression and anxiety by 4 weeks intake of Hericium erinaceus. Biomedical research (Tokyo, Japan), 31(4), 231–237.
  4. Chong, PS (2019). Therapeutic Potential of Hericium erinaceus for Depressive Disorder. International Journal of Molecular Sciences, 21(1), 163.
  5. Okamura, H. (2015). The effects of Hericium erinaceus (Amyloban® 3399) on sleep quality and subjective well-being among undergraduate students: A pilot study. Personalized Medicine Universe, 4, 76–78.
  6. Rodriguez, MN (2022). Lion’s mane (Hericium erinaceus) exerts anxiolytic effects in the rTg4510 Tau mouse model. Behavioral Sciences (Basel, Switzerland), 12(7), 235.
  7. Chiu, CH (2018). Hericium erinaceus mycelium enriched with erinasin A produces antidepressant effects through modulating BDNF/PI3K/Akt/GSK-3β signaling in mice. International Journal of Molecular Sciences, 19(2), 341.
  8. Wang, N. (2022). Effects of Hericium erinaceus polypeptide on lowering blood lipids of high-fat diet-induced hyperlipidemic mice. Journal of Future Foods, 2(4), 346-357.

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