Side effects of lion’s mane

People swear by it lion’s mane mushrooms for their ability to improve overall cognitive function, while others use them as a complementary medicine in the fight against cancer, diabetes or multiple sclerosis.

Are there any side effects to taking lion’s mane? We’ve read the latest studies on the potential dangers of lion’s mane so you don’t have to.

Spoiler alert—the lion’s mane is safe few contraindications.

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What are the side effects of taking lion’s mane?

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How much lion’s mane is in AdaptogenShroomsgranola?

Centuries of use of Hericium erinaceus in traditional Chinese medicine and research by qualified health professionals suggest this Lion’s mane mushrooms are not addictive and they are completeit is safe to consume.

Risks and side effects of lion’s mane

When taking lion’s mane, there is always a remote possibility of side effects such as stomach upset, diarrhea, abdominal discomfort, nausea, and mild skin rashes, but these occur rarely and at high doses. To avoid these side effects, start with a lower dose of mushroom and work your way up.

Lion’s Mane Drug Interactions

Although research on lion’s mane drug interactions is sparse, the mushroom may have some effects that may interfere with medications for medical conditions such as diabetes or blood clotting.

First, lion’s mane appears to have antiplatelet effects. According a study“erikenone B had potent antiplatelet activity and may be a novel compound for antithrombotic therapy possessing a novel mechanism.”

If you are already taking blood thinners, you may want to consult a medical professional about a possible interaction in order to avoid symptoms such as prolonged wound healing and bruising.

Similarly, an animal study on the effects of lion’s mane on diabetic mice suggests that this medicinal mushroom has antihyperglycemic effects, meaning it lowers blood sugar levels. Therefore, if you are already taking antidiabetic medications, you should monitor your blood sugar levels when taking lion’s mane to make sure it does not drop below normal levels.

To learn more about medications that may interact with Hericium erinaceus, check out our guide to lion’s mane drug interactions.

Allergic reactions to lion’s mane

The chances of you having an allergic reaction to lion’s mane are slim. However, if you are prone to allergies or have experienced allergic reactions to fungi or yeast in the past, lion’s mane may not be suitable for you. If you notice any signs of an allergic reaction, stop taking the mushroom immediately and contact a doctor.

Use of lion’s mane during pregnancy

There is no evidence that lion’s mane has an adverse effect on fetal development. Centuries of use suggest it is good for pregnancy and newborns. However, since there are no studies on the safety of this mushroom during pregnancy, you may want to be cautious and consult your doctor if you are trying to conceive a baby.

We go in depth on this topic our article on taking lion’s mane during pregnancy. And, if you want to know about mushroom safety while breastfeeding, take a look Our blog post about lion’s mane and breastfeeding.

Potential health benefits of lion’s mane mushrooms

Lion’s mane mushrooms have a multitude of potential benefits, as they appear to have protective effects throughout the body and improve overall immune function. Many use these medicinal mushrooms for weight loss and weight management, while others praise them for their antioxidant properties.

To learn more about how this amazing mushroom can improve your physical and mental well-being, read our guide to the health benefits of lion’s mane.

Protection against cancer

Some studies indicate that lion’s mane mushrooms appear to induce apoptosis (the process of programmed cell death) of cancer cells and protect against several types of cancer, including leukemia, breast cancer, and stomach cancer.

Encephalosides, compounds found in the fruiting bodies of Hericium erinaceus, show promising therapeutic potential in cancer treatment. Cerebroside E, in particular, appears to help treat cancer, according to an in vitro study. The results of this study “collectively reflect the beneficial effects of [Hericium erinaceus] in the treatment of cancer”.

Neurological health benefits

Lion’s mane shows potential in the overall protection and maintenance of brain health. For one, those nootropic mushrooms appears to preserve cognitive function in people with Alzheimer’s disease and may slow the progression of the disease.

Chemicals found in Hericium erinaceus help promote neurite outgrowth, according to a 2015 study. The mushroom’s ability to promote nerve growth appears to be the main mechanism behind its neurological health properties, such as preventing mild cognitive impairment. damage and overall protection of the nervous system.

A placebo-controlled human study examined the effects of Hericium erinaceus on mild cognitive impairment. This study concluded that “at weeks 8, 12 and 16 of the trial, the [Hericium erinaceus] The group showed significantly increased scores on the cognitive function scale compared to the placebo group.”

In addition, aqueous extracts of lion’s mane show potential in the treatment of Parkinson’s disease due to the mushroom’s neurotrophic properties.

We take a deep dive into the neurological benefits of lion’s mane our article on Hericium erinaceus and neurogenesis. Check it out!

Heart health benefits

According to the CDC, heart disease is the leading cause of death in the United States, with coronary artery disease and heart attacks being the most common.

Health professionals emphasize proper diet and supplement use as the number one way to prevent heart problems, and studies published on the effect of Hericium erinaceus on heart health suggest that the fungus could be an excellent addition to a mindful diet. of health. According to a recent study, “Administration of an ethanolic extract of Hericium erinaceus … resulted in a significant reduction in body weight gain, fat, and serum and hepatic triacylglycerol levels.”

Additionally, a 2010 study found that a compound found in this mushroom appears to reduce platelet aggregation, a mechanism behind the formation of blood clots. Therefore, lion’s mane extracts could be useful in preventing blood clots in people who are prone to thrombosis.

Mental Health Benefits

In addition to cognitive health, Hericium erinaceus appears to help with depression and anxiety relief and overall mental clarity. A double-blind, placebo-controlled study looked at the effects of lion’s mane mushroom on various menopausal symptoms, including anxiety and depression.

Participants who consumed lion’s mane for 4 weeks scored lower on tests measuring symptoms of depressive disorders and anxiety than the control group, meaning they showed fewer signs of these conditions.

Reading our article on taking lion’s mane for depressionas well as on lion’s mane and stressto learn more about the mental health potential of these mushrooms.

Interested in Trying Lion’s Mane?

Lion’s mane is generally safe for most people. However, if you want to take this adaptogenic mushroom and are concerned about possible side effects, it is best to consult a doctor before starting to take a supplement.

 AdaptogenShroomsSuperfood Granola

As soon as your doctor gives you the green light, include the useful mushroom in your diet with us mushroom granola.

Granola is vegan, gluten-free, packed with nutrients and delicious. What more could you want in a breakfast bowl of cereal?

Frequently asked questions about lion’s mane side effects

How much lion’s mane is in AdaptogenShroomsgranola?

AdaptogenShroomsgranola uses a high quality lion’s mane extract made from whole adaptogenic mushrooms. Our double extraction method extracts both water-soluble beta-glucans and alcohol-soluble triterpenes. Our brewing process breaks down the indigestible chitin cell walls of the mushroom to extract far more of these compounds than conventional processes.

One serving of granola provides us with 250 mg of ultra-concentrated lion’s mane extract, which is eight times more concentrated than a regular lion’s mane supplement. So you get as much power in lion’s mane as you would if you were taking a 2000mg mushroom powder supplement, all in a bowl of granola.

Does Lion’s Mane Help Sleep Disorders?

Evidence-based research shows that lion’s mane supplements may improve sleep quality, especially in acute stress-related sleep disorders.

A clinical trial examined the effects of lion’s mane on insomnia caused by exam-related anxiety in Japanese students. Compared to the control group, the students who received the mushroom supplement reported feeling less anxious and had less insomnia after 4 weeks.

To learn more about these benefits, read on our article on the sleep benefits of lion’s mane mushrooms.

Can lion’s mane cause a stomach ulcer?

No, lion’s mane mushroom does not cause stomach ulcers. Instead, these medicinal mushrooms appear to improve digestive health and have gastroprotective properties and may even protect against ulcers, according to an animal study.

To learn more about the beneficial effect of Hericium erinaceus on gut health, read on Our post on lion’s mane for digestion.

How long does it take for lion’s mane to work?

If you take lion’s mane nutritional supplements every day, you should start to notice some changes in two to three weeks. However, don’t be discouraged if you don’t see an immediate improvement in your symptoms and general health.

Continue to take daily supplements of the medicinal mushroom and maybe even increase the amount you consume daily and you will definitely notice the benefits of lion’s mane in a month or so.

Can I take lion’s mane and reishi together?

Yes, you can take lion’s mane mushroom extract with any other type of medicinal fungus or herbal medicine, including reishi mushroom varieties. When it comes to adaptogenic mushrooms, the whole is always greater than the sum of its parts, so the benefits of reishi mushrooms can only be enhanced by taking them with lion brand and vice versa.

Is lion’s mane good for inflammation and oxidation?

Yes, according to medical reviewers as well as alternative medicine practitioners, lion’s mane reduces inflammation and oxidative stress in the body.

A 2022 study examined the anti-inflammatory potential of lion’s mane mushroom extracts and found that two Hericium erinaceus compounds “showed moderate inhibitory effects, indicating their potential anti-inflammatory activity.”

To learn more about this benefit, check out our article on the anti-inflammatory potential of Hericium erinaceus.


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  2. Liang, B. (2013). Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complementary and Alternative Medicines, 13(1).
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