Is lion’s mane effective in treating multiple sclerosis?

Lion’s mane mushrooms they have many proven benefits for your body and mind, but can they really reduce MS symptoms?

Research seems to suggest the answer is yes.

After reading the clinical trials on lion’s mane mushroom and multiple sclerosis, we can say with certainty that lion’s mane appears to relieve the symptoms of this progressive disease.

And now for the finer details of how lion’s mane affects multiple sclerosis.

What is multiple sclerosis?

What does lion’s mane do for multiple sclerosis?

How can lion’s mane relieve the symptoms of multiple sclerosis?

How Much Lion’s Mane Should You Take for Multiple Sclerosis?

How long does it take for lion’s mane to work?

What is the best way to take lion’s mane for multiple sclerosis?

Table of contents

What are lion’s mane mushrooms?

Lion’s mane mushroom (Hericium erinaceus), otherwise known as yamabushitake and monkey head mushroomis a medicinal fungus that has been used in traditional Chinese medicine for centuries.

The fungus grows in Europe, North America and Asia, feeds on dead tree remains, as well as living trees. Although it has been a staple in the East Asian diet since ancient times, researchers are just beginning to examine the mechanisms behind lion’s mane’s many benefits.

Benefits of lion’s mane

Research on health benefits of lion’s mane suggests that the mushroom has significant potential to promote neurite outgrowth and prevent and repair nerve damage. Lion’s mane appears to relieve dementia, depression and anxiety, and neuropathic pain, among other neurological effects.

Hericium erinaceus seems to help:

  • reduction of symptoms of anxiety and depression
  • improving cognitive ability
  • protection against dementia and Alzheimer’s disease
  • improves immune function
  • reducing nerve inflammation and pain
  • encouraging apoptosis of cancer cells
  • reducing the risk of heart disease
  • acceleration of recovery of injuries of the nervous system
  • lowering blood sugar levels
  • reduction of symptoms of neurological disorders, such as Parkinson’s diseaseand Multiple Sclerosis

Lion’s Mane Vitamins and Minerals

The lion’s mane mushroom contains many vitamins, including thiamin, biotin, niacin, folate and vitamin B6. It also contains important minerals for health, such as:

  • calcium
  • iron
  • phosphorous
  • zinc
  • potassium
  • magnesium
  • copper
  • selenium
  • manganese

Lion’s Mane Bioactive Compounds

In addition to vitamins and minerals, lion’s mane mushrooms contain bioactive compounds such as:

  • polysaccharides
  • polypeptides
  • beta-glucoxlan
  • prebiotic fibers
  • digestive enzymes
  • Hericenones
  • hedgehogs

What is Multiple Sclerosis?

Multiple sclerosis (MS, for short) is the most common demyelinating disease, meaning that the source of symptoms lies in progressive damage to the myelin sheath of nerves.

Multiple sclerosis is a progressive disease that still has no cure, although many drugs, as well as herbal remedies, can slow the progression of the disease.

What is the myelin sheath?

The myelin sheath is an insulating layer that forms around nerve cells in the central nervous system, as well as the spinal cord.

These sheaths are mainly found on nerves that must send fast electrical impulses to the brain and are formed, through the process of myelination, along the entire length of the nerve.

Myelin sheaths protect nerves from electrical impulses produced by nearby neurons and help the connected neuron to send impulses faster.

Symptoms of Multiple Sclerosis

The symptoms of MS are caused by the myelin sheaths being unable to do their job due to damage. The immune system attacks the neurons in the brain, which can cause a person with MS to experience the following symptoms:

  • fatigue and weakness
  • vision issues
  • numbness, tingling and mobility problems
  • muscle spasms
  • neuropathic pain
  • weak bladder control and bowel problems
  • libido problems
  • mental health issues (especially anxiety, depression, mood swings and irritability)
  • issues with cognitive functions (problems focusing, thinking and learning)

Is lion’s mane good for multiple sclerosis?

Lion’s mane mushrooms hold great promise for the treatment of multiple sclerosis, both anecdotally and scientifically.

Many people with multiple sclerosis notice an improvement in their symptoms once they start taking lion’s mane mushroom extract. Dr. Terry Wahls, a medical professional who turned to medicinal mushrooms after being diagnosed with multiple sclerosis, and her patients swear by its remyelinating properties.

Although there are no human studies on the effects of lion’s mane on multiple sclerosis, some animal studies have examined the effect of this medicinal mushroom on the myelination process.

For example, one in vitro animal study compared the myelination process in cells with a Hericium erinaceus quote to them without. The results show that the Lion’s mane mushroom extract induced an earlier initiation of the myelination process and provided a higher rate of myelination.

Lion’s mane can relieve the symptoms of multiple sclerosis

People with multiple sclerosis often report that lion’s mane mushrooms significantly reduced the symptoms of their disease. Here’s how adaptogen mushrooms can relieve common symptoms of MS:

Lion’s mane has the potential to relieve neuropathic pain

Neuropathic pain is one of the most common symptoms of multiple sclerosis. Because of the damage to the myelin sheath, the nerves may send signals to your pain receptors, which can cause muscle spasms and sharp pain. So does lion’s mane help neuropathy? Medical News research seems to suggest so.

Some animal studies show that lion’s mane extract has the potential to relieve neuropathic pain. For example, a 2015 study explored its implications Hericium erinaceus on alloxan-induced physiopathic pain in rats. The study concluded that groups of animals treated with the mushroom showed fewer signs of pain-induced oxidative stress after 6 weeks of treatment.

Other animal study focused on the effects of Hericium erinaceus in neuropathic pain induced by spinal nerve ligation in mice. Animals treated with lion’s mane extract showed fewer signs of neuropathic pain and neuroinflammation from the control group.

Lion’s mane can relieve depression and anxiety

MS affects mental health as much as physical health, with anxiety and depression being the most common problems. Fortunately, lion’s mane mushrooms show great potential when it comes to managing mild anxiety and depression.

ONE 2018 study explored its implications Hericium erinaceus on anxiety and depressive-like behaviors in mice. The results suggest that the medicinal mushroom reduced these behaviors by promoting hippocampal neurogenesis.

ONE Japanese human study reached a similar conclusion. In it, participants took a psychological test that measured depressive behavior. They were then divided into two groups, one of which was given a lion’s mane supplement, while the other group was given a placebo. After 4 weeks, the group that received lion’s mane supplementation they scored much lower on the test, meaning that showed less depressive behaviorsfrom the control group.

lion's mane and multiple sclerosis

Lion’s Mane can reduce memory problems

Multiple sclerosis can cause damage to develop in the parts of the brain responsible for processing information, which can lead to memory loss and difficulty learning new skills. However, research shows that, with regular use, lion’s mane may be able to reduce these symptoms of MS.

ONE Japanese study considered its implications Hericium erinaceus in peptide-induced memory and learning deficits in mice. The mice were fed a diet rich in lion’s mane for 23 days. The results show that the mushroom prevented the impairment of short-term and visual recognition memory caused by the peptides.

These findings suggest that Hericium erinaceus it could prevent memory problems caused by diseases such as dementia and multiple sclerosis.

Lion’s mane may help bowel problems associated with multiple sclerosis

People with progressive multiple sclerosis experience a variety of bowel problems, from constipation to irritable bowel syndrome. According to research, the effects of lion’s mane on your intestines can be quite beneficial.

For example, a 2017 study looked at the effects of lion’s mane mushrooms in inflammatory bowel disease. The results show that this medicinal mushroom relieved the symptoms of intestinal inflammation by regulating the gut microflora.

What can we conclude about lion’s mane and multiple sclerosis

Current research on the use of lion’s mane mushroom for multiple sclerosis shows promising results. Here’s what we know so far about it Hericium erinaceus and multiple sclerosis:

  1. According to animal studies, lion’s mane mushrooms hold great promise as a natural treatment for multiple sclerosis due to their remyelinating properties.
  2. Lion’s mane mushrooms can also relieve various symptoms common to MS, such as anxiety and depression, memory problems, bowel problems, and neuropathic pain.
  3. More human studies are needed to learn more about the underlying mechanisms of lion’s mane and its effects on MS.
  4. Given that there is no downside to eating lion’s mane, its relatively low cost and high availability, it may make sense to include medicinal mushrooms in one’s diet as a preventative measure.

Lion’s Mane Dosage Per Day For Multiple Sclerosis

If you are using lion’s mane to manage MS, a higher dose may be more beneficial. Some people with MS report taking 750 mg per day, while others take more than 1000 mg per day. However, if you are new to lion’s mane, you can always start with a lower dose and work your way up over a few weeks.

What time of day should you get the lion’s mane?

It is best to take lion’s mane in the morning or early afternoon, as the mushroom can have a stimulating effect and can make you feel more focused and alert. You can take the lion’s mane at night, but the stimulating abilities of the mushroom can make you feel restless.

How long does Lion’s Mane take to work??

It will take anywhere from two weeks to a few months to notice a difference in your symptoms. Don’t be discouraged if you don’t notice the benefits of lion’s mane right away. Be persistent and take the lion’s mane every day and you will notice the difference before you know it.

I’m interested in Testing lion’s mane for multiple sclerosis?

If you have been diagnosed with multiple sclerosis, there is no harm in including a lion’s mane supplement in your diet and the benefits it could provide are immense. However, it is important to make sure your supplements are top quality.

 AdaptogenShroomsSuperfood Granola
Us AdaptogenShroomsSuperfood Granola is vegan, gluten-free and contains an ultra-concentrated lion’s mane extract, as well as chaga and cordyceps mushrooms. In a breakfast bowl of cereal, you get 10-15 times the nutrient density you would get in a regular mushroom powder, without any mushroom flavor.

Frequently asked questions about lion’s mane and multiple sclerosis

How much lion’s mane is in AdaptogenShroomsgranola?

AdaptogenShroomsgranola uses a high quality lion’s mane mushroom extract made from whole medicinal mushrooms. Our double extraction method extracts both water-soluble beta-glucans and alcohol-soluble triterpenes. Our brewing process breaks down the indigestible chitin cell walls of the mushroom to extract far more of these compounds than conventional processes.

One serving of our granola provides 250 mg of ultra-concentrated lion’s mane extract, which is eight times more concentrated than regular lion’s mane mushroom supplements. So you’re getting as much potency as you would a 2000mg lion’s mane mushroom powder, all in a granola bowl.

Does the lion’s mane cross the blood-brain barrier?

Yes, lion’s mane compounds can cross the blood-brain barrier. The blood-brain barrier serves an important function, the screening of sensitive brain tissues from blood-borne toxins.

While protecting your brain from toxins, the blood-brain barrier also keeps out many beneficial substances.

However, erichenones and erinacins—bioactive compounds found in many adaptogenic mushrooms, including lion’s mane—can cross the blood-brain barrier very easily.

These beneficial compounds stimulate nerve growth factors (NGF) which can provide many benefits, including protection against brain injuries, nerve regeneration (neurogenesis)and myelination.

Is the lion’s mane thinner than blood?

Lion’s mane mushrooms are anticoagulant, meaning they reduce blood clotting. While the adaptogenic mushroom will not act as a blood thinner on its own, it can help with the blood thinning properties of certain medications. Therefore, if you are taking blood thinners, it is best to consult your doctor before you start taking lion’s mane supplements.

Can lion’s mane reverse brain damage?

Yes, research seems to show that lion’s mane mushrooms can reverse brain damage. Hericium erinaceus has a protective effect on the brain. The research suggests that, in case of nerve damage of the central nervous system caused by a stroke or a progressive disease (such as Alzheimer’s disease or MS), the lion’s mane may be able to protect the brain.

Can you get the lion’s mane with antidepressants?

Although anecdotal evidence suggests that it is safe to take lion’s mane with antidepressants, there is no research to date to support this claim. Therefore, if you plan to take lion’s mane in higher doses and are taking antidepressants, be sure to consult your doctor or psychiatrist beforehand.

Can lion’s mane regenerate nerves?

Yes, studies indicate that lion’s mane shows the ability to regenerate nerves and even create new neurons. The bioactive compounds found in the medicinal mushroom, ericeones and erinacins, stimulate the production of nerve growth factor (NGF) proteins. and the production of brain-derived neurotrophic factor. The proteins NGF and BDNF, in turn, stimulate the creation of new neurons as well as the regeneration of existing ones.

Can you get a lion’s mane mushroom and a reishi mushroom together?

Yes, you can take lion’s mane mushrooms with any other type of medicinal mushroom, including the reishi and shiitake mushroom varieties. When it comes to adaptogenic mushrooms, the whole is always greater than the sum of its parts, so the benefits of reishi mushrooms can only be enhanced by taking them with lion brand and vice versa.

Does lion’s mane work immediately?

If you take a lion’s mane supplement every day, you should start to notice some changes in two to three weeks. However, don’t be discouraged if you don’t see an immediate improvement in your symptoms and general health. Continue to take daily medicinal mushroom supplements and maybe even increase the amount you consume daily and you will definitely notice changes in a month or so.

What are the negative effects of lion’s mane?

Lion’s mane has no known side effects. Although no evidence-based studies have been conducted on the negative effects of Hericium erinaceus, anecdotal evidence and centuries of use suggest that lion’s mane is completely safe for consumption, both as a food and as a dietary supplement.

What is the ideal lion’s mane dosage for neuropathy?

Lion’s mane appears to relieve neuropathic pain. To reap this benefit of lion’s mane, take 500-1000 mg of Hericium erinaceus 1-3 times a day. Because the exact dosage will vary from person to person, you should experiment until you find the ideal lion’s mane dosage for you.

What is the best mushroom for multiple sclerosis?

Lion’s mane appears to be the best mushroom for treating multiple sclerosis. Although this fungus cannot replace medication for multiple sclerosis, it is an amazing natural remedy with proven abilities to relieve multiple symptoms of this and many other neurological diseases.

When should you not take the lion’s mane?

Hericium erinaceus extract and supplements are generally safe for the majority of people. However, if you are allergic or sensitive to mushrooms, or if you have a history of allergy to mushrooms, lion’s mane may be contraindicated for you. If you notice any signs of an allergic reaction (such as a skin rash or difficulty breathing), stop using lion’s mane and consult a doctor.

Bibliographical references:

  1. Kolotushkina, EV (2003). The effect of Hericium erinaceus extract on the myelination process in vitro – PubMed. PubMed. Retrieved January 27, 2023, from
  2. Yi, Z. (2015). Protective effect of ethanolic extracts of Hericium Erinaceus on alloxan-induced diabetic neuropathic pain in rats. Retrieved January 27, 2023, from
  3. Yang, PP (2020). Effects of Hericium Erinaceus Mycelium Extracts on Purinoreceptor Functional Activity and Peripheral Nerve Nociception in L5 Spinal Ligation Mice. Retrieved January 27, 2023, from
  4. Ryu, S. (2018). Hericium erinaceus extract reduces anxiety and depressive-like behaviors by promoting hippocampal neurogenesis in the adult mouse brain. Journal of Medicinal Food, 21(2), 174–180.
  5. Nagano, M. (2010). Reduction of depression and anxiety by 4 weeks of Hericium Erinaceus intake. Retrieved January 27, 2023, from
  6. Mori, K. (2011). Effects of Hericium Erinaceus on learning and memory deficits induced by amyloid beta peptides in mice. Retrieved January 27, 2023, from
  7. Diling, C. (2017, September 6). Hericium erinaceus extracts relieve inflammatory bowel disease by regulating immunity and gut microflora. PubMed Central (PMC). Retrieved January 27, 2023, from
  8. Wong, KH (2009). Improvement of functional recovery after rodent peroneal nerve injury by the lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae). International Journal of Medicinal Mushrooms, 11(3), 225–236.
  9. Lee, KF (2014). Protective Effects of Hericium erinaceus Mycelium and Isolated Erinacin A against Ischemia-Injury-Induced Neuronal Cell Death Through Inhibition of MAPK iNOS/p38 and Nitrotyrosine. MDPI. Retrieved January 27, 2023, from
  10. Zhang, CC. (2015). Chemical constituents from Hericium Erinaceus and their ability to stimulate NGF-induced neurite outgrowth in PC12 cells – ScienceDirect. Retrieved January 27, 2023, from

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