Can You Take Lion’s Mane For Arthritis?

In case you are taking lion’s mane mushrooms to relieve the symptoms of arthritis? According to research, the answer is yes! This mushroom appears to reduce the pain and inflammation associated with arthritis. Let’s get into the details and benefits.

What are the benefits of lion’s mane mushrooms?

What are the negative effects of lion’s mane?

Should You Take Lion’s Mane For Arthritis?

How can you take lion’s mane for arthritis?

How Much Lion’s Mane Should You Take for Arthritis?

How much lion’s mane is in AdaptogenShroomsgranola?

What is a lion’s mane?

The lion’s mane mushroom (Yamabushitake, Hericium erinaceus), which is native to North America, Europe and Asia, is a adaptogenic mushroom which has been used in traditional Chinese medicine for centuries. Due to the benefits it provides for physical and mental health, this fungus is one of them the healthiest mushrooms you can eat.

Benefits of lion’s mane

Research on the potential health benefits of lion’s mane mushrooms shows that this fungus has the ability to promote nerve regeneration through the production of nerve growth factor proteins and thereby repair brain cells. It appears to lower blood sugar levels, reduce oxidative stress, and improve brain function and neuronal health.

Some of the potential benefits of lion’s mane include:

  • reduces the symptoms of mental health conditions such as depression and anxiety
  • provides anti-inflammatory effects
  • improves overall brain health and cognitive functions, including learning and memory
  • has a protective effect on the nervous system, repairs nerve cells and improves recovery after brain damage
  • improves heart health, reduces the risk of high blood pressure, heart disease and blood clots
  • promotes neurite outgrowth
  • helps with weight loss and weight management
  • prevents memory loss and protects against mild cognitive impairment
  • lowers blood sugar
  • encourages apoptosis (cell death) of cancer cells and has the potential to fight cancer
  • improves the health of the digestive system and prevents stomach ulcers and inflammatory bowel diseases
  • strengthens the immune system and improves immune function
  • has neuroprotective properties and reduces nerve damage in neurodegenerative diseases such as multiple sclerosis, Parkinson’s and Alzheimer’s

Contraindications for lion’s mane

Centuries of use and anecdotal evidence suggest so Lion’s mane is completely safe to eat; There is no research to suggest lion’s mane is unsafe. However, there are some contraindications to taking Hericium erinaceus.

Lion’s mane extracts may cause allergic reactions or asthma attacks in rare cases and may interact with certain medications. As a result, lion’s mane may be contraindicated for people who are allergic to fungi, mold, or yeast, have severe asthma, or take medications that interact with Hericium erinaceus.

Lion’s mane and arthritis

Based on its promising results herbal research for the treatment of arthritis, many people turn to herbs and fungi to relieve their symptoms. Lion’s mane appears to help all types of arthritis, including rheumatoid arthritis, psoriatic arthritis, and osteoarthritis, by reducing pain and swelling.

Lion’s Mane Studies on Arthritis

One animal study conducted in 2022 examined the effects of lion’s mane on osteoporosis in Sprague-Dawley rats. According to the findings of this study, lion’s mane can significantly reduce arthritis pain.

Also, this mushroom appears to inhibit the production of pro-inflammatory cytokines that promote arthritis. Although more human research is needed on the effects of lion’s mane on arthritis, it is safe to say that this mushroom can help those suffering from arthritis.

Lion's mane for arthritis

Does lion’s mane help with inflammation?

Chronic inflammation is a symptom of arthritis. Lion’s mane reduces inflammation and oxidation in the bodyand research shows that its anti-inflammatory properties may be especially beneficial for those suffering from chronic inflammation.

ONE recent study on the anti-inflammatory effects of Hericium erinaceusfor example, found that lion’s mane extracts exhibited anti-inflammatory effects by inhibiting TLR4-JNK signaling.

According 2019 study, the TLR4-JNK pathway promotes inflammation. Lion’s mane appears to reduce inflammation levels in adipose tissue, which is associated with obesity and is generally prone to chronic inflammation.

Does lion’s mane help with pain?

According to animal studies published in the Journal of Ethnopharmacology and the International Journal of Medicinal Mushrooms, Lion’s mane mushrooms may be useful in treating neuropathic pain. For example, a 2019 animal study examined the effects of Hericium erinaceus on cisplatin-induced peripheral neuropathy.

Cisplatin is a highly effective anticancer drug commonly used to treat solid tumors. People who take it in high doses, on the other hand, often experience neuropathic pain. This severely limits the dose that cancer patients can receive, as well as the effectiveness of the drug.

In this study, half of the animals received both cisplatin and a warm aqueous extract of lion’s mane, while the other half received only cisplatin. Analysis of changes in body weight, electromyographic (EMG) measurements, and immunohistochemistry techniques show that Hericium erinaceus helped treat peripheral neuropathy in a mouse model.

The neuropathy-relieving activity of lion’s mane warrants further investigation, particularly in human subjects. In the meantime, if you suffer from neuropathic pain caused by arthritis, there is no harm in including this mushroom in your diet as an alternative medicine.

Try the best lion’s mane supplement for arthritis

If you are interested in taking lion’s mane for arthritis, you are in the right place. We provide a delicious functional mushroom granola containing high quality lion’s mane extract.

The granola is gluten-free, vegan and nutrient-dense. What more could you want in a breakfast bowl of cereal?

 AdaptogenShroomsSuperfood Granola

What is the ideal lion’s mane dosage for arthritis?

To reduce neuropathic pain and inflammation associated with arthritis, it is best to take about 500–1000 mg of Hericium erinaceus 1–3 times a day. The best lion’s mane dosage it may vary slightly from person to person, so you should experiment until you find the most effective dose for you. Lion’s mane doesn’t seem to interact with conventional arthritis treatments, so it’s safe to get this Hericium erinaceus effect, even if you’re using prescription drugs.

How much Lion’s Mane is in AdaptogenShroomsSuperfood Granola?

AdaptogenShroomsgranola uses a high quality lion’s mane mushroom extract made from whole medicinal mushrooms. Our double extraction method extracts both water-soluble beta-glucans and alcohol-soluble triterpenes. Our brewing process breaks down the indigestible chitin cell walls of the mushroom to extract far more of these compounds than conventional processes.

One serving of our granola has 250 mg of ultra-concentrated lion’s mane extract, which is eight times more concentrated than regular lion’s mane supplements. Therefore, you get as much potency as you would a 2000mg dose of lion’s mane powder, all in a bowl of granola.

Frequently asked questions about lion’s mane for arthritis

Can lion’s mane cause inflammation?

No, lion’s mane does not cause inflammation. This mushroom is one of the best mushrooms for inflammationas it facilitates chronic inflammatory processes in the body.

Can I take lion’s mane daily?

Taking lion’s mane mushrooms daily is not only completely safe but also extremely beneficial. The long-term benefits — such as the ability of lion’s mane to relieve OCD symptoms and prevent diabetes – become more apparent the more you use this mushroom.

Can lion’s mane cause nerve damage?

No, lion’s mane does not cause nerve damage. Instead, a major benefit of lion’s mane appears to be that it helps prevent nerve damage. Neuropathic pain, which is a common symptom of nerve damage, is also relieved by lion’s mane.

Lion’s mane may also reduce nerve damage caused by dementia. ONE double-blind, placebo-controlled clinical trial examined the effects of lion’s mane on mild cognitive impairment.

Participants’ ages ranged from 50 to 80. For 16 weeks, half of the participants in the Japanese study were given lion’s mane supplements, while the other half received a placebo.

Participants who received the mushroom supplement performed better in terms of cognitive function. These significant increases suggest that lion’s mane supplements have the potential to protect neurons and improve brain function.

Does lion’s mane affect hormones?

Studies show that lion’s mane mushrooms may be able to influence hormone production by causing nerve cells to grow, especially in the hypothalamus of the central nervous system. Hericium erinaceus, a well-known nootropic, appears to stimulate neurogenesis.

Compounds found in the fruiting body of lion’s mane promote the production of brain-derived nerve growth factors. BDNF, in turn, regulates hypothalamic hormone production (growth hormone, vasopressin, adrenocortical hormones, and others).

These medicinal mushrooms may regulate hormone production by stimulating BDNF. This calls for more research into the effects of Hericium erinaceus on hormones, particularly in humans.

How do lion’s mane mushrooms make you feel?

Lion’s mane is known to reduce anxiety and depressive disorders, so you can expect your mood to improve if you take the fungus regularly. You will also likely experience many more amazing benefits, such as feeling clearer and more focused, due to the beneficial effect of Hericium erinaceus on cognitive functions.

Does lion’s mane thin your blood?

No, lion’s mane does not thin your blood, but it can interact with medications that do (antiplatelet medications). Certain health conditions that cause blood clotting problems, such as hemophilia, can also be affected by lion’s mane. Therefore, it is best to talk to a healthcare professional about the possible effects of mushroom supplementation before taking a lion’s mane dietary supplement if you are antiplatelet or have hemophilia.

What are the spiritual benefits of lion’s mane?

Available research and centuries of use in alternative health and wellness suggest that lion’s mane mushrooms can have spiritual benefits. The lion’s mane has spiritual effects This is seen in its ability to improve focus and memory, calm stress and improve mental health overall. Shaolin monks in ancient China used lion’s mane on a daily basis to improve their concentration. It was believed to strengthen ‘Chi’, a mystical, energizing life force.

Does lion’s mane interact with medications?

Since this mushroom prevents blood clotting, Lion’s mane could interact with medications which have the same effect (such as aspirin, heparin and warfarin) and slow down clotting and wound healing. The beneficial effect of lion’s mane on blood sugar levels can cause this mushroom to interact with diabetes medications. If you are taking anticoagulants or are diabetic, it is best to consult a healthcare professional before starting to take lion’s mane.

Can I get the lion’s mane with the reishi mushroom?

Yes, you can combine lion’s mane with any medicinal mushroom, including reishi. When it comes to medicinal mushrooms, the whole is greater than the sum of its parts, so combining lion’s mane with other adaptive fungi will likely yield higher therapeutic potential.


  1. CVA, K. (2017). Phytotherapy in the treatment of arthritis: a review. Journal of Orthopedics & Bone Disorders, 1(7).
  2. Yang, SY (2022, June 23). Hericium erinaceus Mycelium Ameliorates Osteoarthritis Progression in Vivo. MDPI. Retrieved January 23, 2023, from
  3. Mori, K. (2015). The anti-inflammatory effects of the medicinal lion’s mane mushroom, Hericium erinaceus (Higher Basidiomycetes) in a co-culture system of 3T3-L1 adipocytes and RAW264 macrophages.International Journal of Medicinal Mushrooms,17(7), 609–618.
  4. Lee, W. (2019). TLR4 promotes liver inflammation by activating the JNK pathway – PubMed. PubMed. Retrieved January 23, 2023, from
  5. Üstün, A. (2019). Therapeutic effect of Hericium erinaceus in an experimental model of peripheral neuropathy. EBSCOhost | 137698148 | Therapeutic Effect of Hericium Erinaceus in an Experimental Model of Peripheral Neuropathy. Retrieved January 23, 2023, from vowlpmVSx9J3PA8sQ3hJATSpTFVdJW4QrPcg%3d%3d&crl=c&result Ns=AdminWebAuth&resultLocal=ErrCrlNotAuth&crlhashurl=login.aspx%3fdirect%3dtrue 26profile% 3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d13078798%26AN%3d137698148
  6. Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009, March). Improving effects of Yamabushitake mushroom (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367-372.
  7. Lai, PL (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. International Journal of Medicinal Mushrooms, 15(6), 539–554.

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