Can Lion’s Mane Mushrooms Fight Parkinson’s Disease?

While we can’t claim that the lion’s mane can treatment Parkinson’s, it certainly seems to work against the disease.

This has been proven Hericium erinaceus promotes neurogenesis (development of brain nerve cells). Parkinson’s disease does the exact opposite, destroying integral parts of the brain as the disease progresses.

Lion’s mane promotes the growth of neurons. Parkinson’s destroys neurons. The two seem to be in direct opposition to each other. Draw your own conclusions.

Let’s get into the finer points of the science behind the lion’s mane, neurogenesis and Parkinson’s disease.

What is Parkinson’s disease?

Can lion’s mane relieve Parkinson’s disease?

Does the lion’s mane revive the nerves?

How does neurogenesis affect Parkinson’s disease?

Can the neuroprotective properties of lion’s mane benefit Parkinson’s patients?

Does lion’s mane alleviate neurotoxicity associated with Parkinson’s disease?

How to take lion’s mane for Parkinson’s disease?

What are lion’s mane mushrooms?

lion’s mane (Hericium erinaceus) it is one incredibly healthy edible mushroom which is commonly grown in North America, Asia and Europe. Because of its many beneficial properties, lion’s mane has been used in traditional Chinese medicine for centuries. These medicinal mushrooms they are saprotrophic, meaning they feed on organic matter found in dead trees.

Benefits of lion’s mane mushroom

Research on health benefits of lion’s mane mushroom suggests that this fungus has the potential to promote the production of nerve growth factor proteins and repair nerve cells. It appears to have anti-depressant effects, provide anti-inflammatory properties, relieve dementia symptoms, reduce oxidative stress, as well as improve overall mental clarity and neuronal health.

Some of the potential benefits of lion’s mane include:

  • reduces symptoms of depression and worry
  • reduces inflammation and nerve pain
  • improves overall brain function, including learning and memory
  • has a protective effect on the brain and improves brain health
  • reduces the risk of heart disease and blood clots
  • prevents memory loss and protects against mild cognitive impairment
  • lowers blood sugar levels
  • encourages apoptosis (cell death) of cancer cells
  • improves digestive health
  • strengthens the immune system and improves immune function
  • has neuroprotective properties and reduces brain damage in neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease

Lion’s Mane Bioactive Compounds

Hericium erinaceus contains a multitude of bioactive compounds, such as:

  • polysaccharides
  • beta-glucoxlan
  • polypeptides
  • digestive enzymes
  • prebiotic fibers
  • Hericenones
  • hedgehogs

While many of these compounds are just beginning to be understood by science, some are known to have profound effects. For example, the ericiones, found in the fruiting bodies of the lion’s mane, and the erinacins, found in the mycelium of the fungus, they have incredible neurotrophic potential.

What is Parkinson’s disease?

Parkinson’s disease is a progressive neurodegenerative disease caused by the loss of nerve cells in parts of the brain that produce dopamine (mainly a part called the substantia nigra).

Since dopamine plays an important role in regulating body movements, this disease manifests itself as stiffness and difficulty walking, although other symptoms may be present, especially as the disease progresses.

Prevalence of Parkinson’s disease

According to Parkinson Foundation, nearly one in a million people in the US are diagnosed with Parkinson’s disease, with men 1.5 times more likely to develop it than women. Worldwide, more than 10 million people live with this disease.

Symptoms of Parkinson’s disease

The four main symptoms of Parkinson’s disease, found in almost every case of this disease, are:

  • tremors of hands, feet, jaws and head
  • slowness of movement
  • stiffness of the limbs
  • impairment of balance and coordination

Less common symptoms include depression and other mental health problems, urinary problems, constipation, sleep problems, skin problems, and difficulty swallowing and speaking. These symptoms are more common in the later stages of the disease.

Is lion’s mane good for Parkinson’s disease?

Unfortunately, there is a serious lack of human research regarding the effects of lion’s mane on Parkinson’s disease. However, anecdotal evidence and animal studies show this Lion’s mane mycelium can be very effective in treating damaged brain neurons to recovery in cases of Parkinson’s disease.

The effectiveness of the mushroom in the treatment of other neurodegenerative diseases (such as results of Hericium erinaceus for Alzheimer’s disease), anecdotal use and the few available studies suggest this Lion’s mane can be extremely beneficial for Parkinson’s disease due to its ability to repair damaged nerves and stimulate the growth of new ones.

Despite the lack of clear research on lion’s mane and Parkinson’s disease, here are the facts:

  • Lion’s mane appears to promote neurogenesis (neuron cell growth)
  • Parkinson’s is a disease of neuronal cell death
  • Lion’s mane and Parkinson’s disease are in direct opposition to each other: one promotes the growth and the other the decay of nerve cells.

You can make your own assumptions about lion’s mane and its effectiveness in treating Parkinson’s disease. We think it is quite safe to assume that the action of the mushroom in the disease can only be beneficial, especially as lion’s mane has no known negative side effects.

What does lion’s mane do to the brain?

When it comes to nerve regeneration and nerve regeneration, lion’s mane extracts are unmatched, according to research. ONE study published in the Journal of Restorative Medicine examined his neurological activity Hericium erinaceus.

The results suggest that the Bioactive compounds found in lion’s mane (especially ericenones and erinacins) appear to have neuroprotective and neuroregenerative properties.

A 2015 study looked at the effects of medicinal mushrooms such as Lignosus rhinocerotis (higher basidiomycetes), otherwise known as tiger’s milk, and Hericium erinaceus on nerve development.

The results suggest thathe adaptogenic mushrooms stimulate neurite outgrowth in dissociated cells of the brain, spinal cord and retina and promote the production of nerve growth factor gene expression.

Nerve Development, Parkinson’s Disease and Lion’s Halitis

One in vitro study looked at the effects of medicinal mushrooms, including lion’s mane, on neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Of the 2000 adaptogenic mushrooms tested, only a few were confirmed to promote nerve growth.

Hericium erinaceusIn particular, it has been shown to be beneficial for the health of neurons, as it has the ability to regenerate peripheral nerves and helps produce new neurons (neurogenesis). A 50 μg/mL mane extract triggered the growth of nerve cells in the brain, spinal cord, and retinal cells.

How neurogenesis affects Parkinson’s disease: an animal study

Well, it’s obvious that Lion’s mane mushroom extract may help with neuron production increasing levels of nerve growth factor (NGF) proteins. But can neurogenesis really improve the symptoms of Parkinson’s disease? Research shows it does.

ONE comparative study examined the effects of NGF on the development and severity of Parkinson’s disease. The results suggest that the decrease in NGF levels may reflect ongoing neurodegenerative processes in Parkinson’s disease, as patients with this disease showed a significant decrease in the production of this protein in later stages of the disease.

Although more research is needed on the effects of nerve growth factor proteins on Parkinson’s disease, it is certainly a topic worth looking into, as it is very possible that NGF may slow the progression of this disease.

Neuroprotective properties of lion’s mane

One animal study published in the International Journal of Molecular Sciences examined its neuroprotective effects Hericium erinaceus mycelium extract in PC12 cells.

PC12 cells are derived from rats and are often used in animal research to learn about the underlying mechanisms of brain disorders at the cellular level.

The results of this study show that the aqueous extract of lion’s mane fruiting bodies successfully induced the differentiation and formation of PC12 cells.

Due to the neuroprotective properties of this adaptive mushroom, mice given the mushroom extract showed significant improvements in cognitive functions and processes.

The The mushroom extract appeared to improve the results of various tests measuring recognition memory in wild-type miceincluding water maze tests and rotarod tests.

Lion’s Mane and Remyelination

Lion’s mane mushrooms appear to promote remyelination, making them a popular mushroom choice for people with chronic neurological disorders such as multiple sclerosis and Alzheimer’s disease.

An in vitro animal study compared the myelination process in cells with Hericium erinaceus extract to those without. The results show that the Lion’s mane mushroom extract induced an earlier initiation of the myelination process and provided a higher rate of myelination.

Parkinson’s disease destroys myelin, which is the main cause of movement problems and other symptoms of this disease. Therefore, taking lion’s mane could lead to improved motor function in Parkinson’s patients.

Lion’s mane and Parkinson’s-related neurotoxicity

Studies on the effects of lion’s mane on Parkinson’s disease are rare, but some animal studies show promising results. For example, a Animal study 2020 considered its implications Hericium erinaceus on neurotoxicity associated with Parkinson’s disease.

According to the results of this study, the mice given lion’s mane extract showed fewer signs of neuronal cell cytotoxicity thanks to the protective effects of erinacin A, a compound found in this adaptogenic mushroom.

Lion’s Mane Dosage for Parkinson’s disease

To reap the benefits that lion’s mane can have for Parkinson’s patients, you should take this mushroom every day for at least a month. Start with a low dose (about 250 mg) if you are not used to adaptogenic mushrooms and steadily increase the dose until you reach about 3000 mg or start to notice an improvement in your symptoms.

What can we say definitively? The lion’s mane and Parkinson’s disease

Here’s what we know so far Hericium erinaceus and Parkinson’s disease:

  1. The neurotrophic effects of lion’s mane could be extremely beneficial for the treatment and prevention of Parkinson’s disease, according to both animal and cell studies.
  2. The production of nerve growth factor (NGF) protein appears to slow the progression of Parkinson’s disease, at least in animals.
  3. Lion’s mane improves cognitive function and its neuroprotective effects Hericium erinaceus could help treat Parkinson’s disease by slowing the cognitive decline associated with the disease.
  4. Lion’s mane appears to prevent neurotoxicity associated with Parkinson’s disease, at least in animals.
  5. More human studies are needed to reveal the underlying mechanisms of lion’s mane and its effects on Parkinson’s disease.
  6. Since there are no downsides to taking lion’s mane, its low cost and high availability, it may make sense to include this fungus in one’s diet as a way to slow the progression of Parkinson’s disease.

I am interested in Effort Lion’s Mane for Parkinson’s disease?

If you are interested in trying lion’s mane mushrooms for Parkinson’s disease, we recommend that you do so with AdaptogenShroomsSuperfood Granola.

Mushroom  AdaptogenShroomsgranola

Why; Well, for one, it’s delicious granola that you’ll be ecstatic to devour every morning. And most importantly, this granola is gluten free, vegan and super healthy. Contains an ultra-concentrated lion’s mane extract, as well cordyceps and chaga extracts.

Choose one of our three delicious flavors: cocoa sunflower seed, cinnamon or vanilla almond. Alternatively, go with a bundle of all three flavors if you can’t decide or just want a variety of flavors to start your mornings.

Frequently asked questions about lion’s mane and Parkinson’s disease

Which mushroom is good for Parkinson’s disease?

Thanks to its neurogenetic properties, Hericium erinaceus has unparalleled benefits for Parkinson’s patients. Some mushrooms that also seem to relieve Parkinson’s symptoms are Grifola frondosa, Ganoderma lucidum, and Lignosus rhinocerotis.

What are the side effects of lion’s mane?

There are no known serious ones contraindications of lion’s mane. The most common lion’s mane side effect that people experience is indigestion which disappears after a few days of use. However, if you want to avoid digestive problems, start with a low dose and work your way up once your body gets used to the mushroom.

How long does it take for lion’s mane to work?

It usually takes about two weeks of taking lion’s mane mushroom powder or extract to notice the benefits of lion’s mane, and it can take even longer, depending on how much you take and what you’re taking it for. Don’t get discouraged if you don’t see immediate results, keep at it and increase the dosage slightly and the results will come.

How does a lion’s mane make you feel?

Lion’s mane supplements can have a stimulant effect and therefore can make you feel more energetic and focused, but can also make you anxious if you take it late in the day. People suffering from anxiety also report feeling more relaxed after taking lion’s mane due to its soothing properties.

Does the lion’s mane revive the nerves?

Yes, according to research, lion’s mane appears to have neurotrophic properties. Because of its ability to regenerate and repair damaged nerves, lion’s mane is a popular dietary supplement for people with cognitive impairment caused by nerve damage caused by disease or injury.

Is Lion’s Mane addictive?

No, lion’s mane is not addictive, even if you use it for a long time and at a high dose. You can stop taking it at any time without repercussions, although you will stop experiencing the many benefits this adaptogenic mushroom provides once you do.

Does Lion’s Mane Help Peripheral Neuropathy?

Although more research is needed on the effects of lion’s mane on peripheral neuropathy, the results of existing studies are promising. Research in lion’s mane and diabetes seems to confirm that this mushroom can be quite beneficial in treating this common symptom of diabetes and can relieve nerve pain in people with trauma-related nerve damage as well.

Is the lion’s mane psychedelic?

No, Lion’s Mane is not psychedelic and cannot get you high. Mushrooms that can cause an overdose contain a compound called psilocybin, a natural psychedelic substance that can alter your state of mind.

As lion’s mane does not contain psilocybin or other psychoactive compounds, there is no risk of breaking out from eating the mushroom.

Can I take lion’s mane with other medicinal mushrooms?

Yes, you can take lion’s mane with other medicinal mushrooms such as cordyceps, turkey tail, maitake mushroom and reishi mushroom. When it comes to medicinal mushrooms, the whole is better than the sum of its parts, so you’ll likely get more benefits from lion’s mane if you take it with any other adaptogenic fungus.


  1. Mom, BJ. (2010). Ericenones and erinacins: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus
  2. Spelman, K. (2017). Neurological activity of lion’s mane (Hericium erinaceus)
  3. Samberkar, S. (2015). The medicinal mushrooms of lion’s mane, Hericium erinaceus, and tiger’s milk, Lignosus rhinocerotis (Higher Basidiomycetes) stimulate neurite outgrowth in dissociated brain, spinal cord, and retinal cells: An in vitro study
  4. Kolotushkina, EV (2003). The effect of Hericium erinaceus extract on the myelination process in vitro
  5. Pedre, LL (2002). Nerve growth factor levels in Parkinson’s disease and experimental parkinsonian rats
  6. Zhang, J. (2016). The neuroprotective properties of Hericium erinaceus in glutamate-depleted differentiated PC12 cells and a mouse model of Alzheimer’s disease
  7. Lee, KF. (2020). After treatment with Erinacin A, a diterpenoid derived from H. erinaceus, attenuates neurotoxicity in the MPTP model of Parkinson’s disease

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