Can Lion’s Mane Help Vagus Nerve Problems?

Struggling with indigestion or anxiety? A malfunctioning vagus nerve may be at the root of your health problems.

Fortunately, lion’s mane appears to provide benefits for the entire nervous system, including the vagus nerve. Learn how this medicinal mushroom can help your vagus nerve function properly and improve your overall health.

What are the benefits of lion’s mane?

What are the negative effects of lion’s mane?

How can lion’s mane heal the vagus nerve?

How to take lion’s mane for vagus nerve benefits?

How Much Lion’s Mane to Take for Vagus Benefits?

How much lion’s mane is in AdaptogenShroomsgranola?

To learn more about the many benefits and uses of this amazing mushroom, check out our detailed guide to lion’s mane mushrooms.

What is a lion’s mane?

The lion’s mane mushroom (Hericium erinaceus) is an adaptogenic mushroom that has been used for centuries in traditional Chinese medicine and is still considered one of the the healthiest mushrooms in alternative medicine. This type of mushroom thrives in milder areas and is native to Northern Europe, Asia and North America.

To learn more about what makes these edible mushrooms and other adaptogens amazing, read our guide to adaptogenic mushrooms.

Benefits of lion’s mane

Lion’s mane mushrooms have been used for centuries to boost brain function and improve overall health. Recent scientific studies have confirmed many of the potential benefits of this powerful mushroom. Here are some key benefits of lion’s mane mushrooms:

  • Enhances cognitive function: lion’s mane contains compounds that promote the growth and repair of nerve cells in the brain, which can lead to improved cognitive function, memory and mood.
  • Helps relieve anxiety and depression: some studies have shown this Lion’s mane mushrooms may help reduce symptoms of depression and anxiety, possibly by regulating neurotransmitters such as serotonin and dopamine.
  • It can prevent Alzheimer’s and Parkinson’s diseases: research has shown that lion’s mane may have neuroprotective properties that could help prevent or slow the progression of these degenerative brain diseases.
  • Provides antioxidant activities: lion’s mane mushrooms contain antioxidants that can help protect cells from oxidative stress, which is a major contributor to aging and disease.
  • Helps regulate blood glucose levels: Lion’s mane mushrooms contain compounds that may help regulate blood sugar levels, potentially making them a useful dietary addition for people with diabetes or metabolic disorders.

Incorporating this powerful mushroom into your diet can provide a natural way to support your overall wellness, as well as prevent many diseases. To learn more about how Hericium erinaceus can improve your life, check out our article on the health benefits of lion’s mane.

Side effects of lion’s mane

Centuries of use and available research suggest so there are no long-term side effects from taking lion’s mane mushrooms. Some people experience short-term digestive discomfort when they start taking this adaptogenic mushroom, but these side effects usually subside within a few days.

There are some contraindications to taking Hericium erinaceus, however. This fungus can cause an allergic reaction if you are prone to mold, yeast and fungus allergies.

Lion’s mane may also interact with certain medications, such as antidiabetics and anticoagulants. To learn more about taking lion’s mane with medicine, read our guide to lion’s mane drug interactions.

What is the vagus nerve?

The vagus nerve is the 10th cranial nerve and is one of the longest and most complex nerves in the body. It is the main nerve of our parasympathetic nervous system, which means its function is to calm us down and help us relax. Some of the functions that the vagus nerve regulates are:

  • blood pressure and heart rate
  • digestive processes such as gastric secretion and peristalsis
  • respiratory functions, including breathing depth and breathing rate;
  • immune system responses and inflammation
  • reducing stress and anxiety
  • rest, relaxation and sleep quality

Effects of lion’s mane on the vagus nerve

Unfortunately, there is no research on the effects of lion’s mane on the vagus nerve, specifically.

But lion’s mane seems to be good for nerve growth and regeneration, so it’s safe to assume that this mushroom can help the vagus nerve work better.

Let’s take a look at how lion’s mane can help with nerve growth and regeneration, and how it can improve certain functions of the vagus nerve.

Lion's Mane for the vagus nerve

Does lion’s mane cure nerves?

Lion’s mane appears to help regenerate peripheral nerves, at least in animals. One animal study examined the effects of lion’s mane extract from fresh fruit bodies on peroneal nerve injuries in rats. The results show that lion’s mane mushrooms stimulate nerve regeneration after peripheral crush injury.

Another study, published in 2012, looked at the underlying mechanisms of lion’s mane’s ability to regenerate nerves. According to this study, lion’s mane activates MAPK signaling pathways, which are involved in mediating neurite growth and regeneration.

Can lion’s mane promote nerve growth?

Lion’s mane is one of the most powerful neurotrophic supplements and research shows that it can improve nerve growth.

ONE 2014 study examined the mechanisms behind the neurite outgrowth stimulatory effects of Hericium erinaceus. According to this study, lion’s mane stimulated nerve growth factors by activating signaling pathways involved in neurogenesis (MEK/ERK and PI3K-Akt pathways).

ONE recent study published by the University of Queensland’s Brain Institute found that “the lion’s mane mushroom had a significant impact on brain cell growth,” confirming previous research that these mushrooms enhance memory by stimulating nerve growth.

Many more studies examine the benefits of lion’s mane in nerve development. Read our article on lion’s mane and neurogenesis to learn more about this amazing benefit.

Can lion’s mane improve digestion?

Research shows that there is a link between digestive problems such as excess gut microflora and poor vagus nerve function. Through its beneficial effects on gut health, lion’s mane can alleviate these problems and thus help your vagus nerve to function properly.

In a Animal study 2017, researchers examined the effects of Hericium erinaceus on inflammatory bowel syndrome (IBS) in rats. The results showed a significant improvement in histological results in IBS rats after two weeks of treatment, indicating that lion’s mane reduced IBS symptoms.

To learn more about the benefits of Hericium erinaceus for your gut, take a look our article detailing the digestive benefits of lion’s mane mushrooms.

Want To Get The Lion’s Mane For Vagus Nerve Benefits?

If you are interested in taking lion’s mane for its vagus benefits, give us functional mushroom granola a test.

One serving of our delicious granola contains your daily dose of lion’s mane extract. Plus, the granola is vegan, gluten-free, and packed with delicious, nutritious ingredients. What more could you want from a breakfast bowl of cereal?

 AdaptogenShroomsSuperfood Granola

Lion’s Mane Dosage for Vagus Nerve Benefits

Due to the lack of research on the effects of lion’s mane on the vagus nerve in humans, there is no way to determine the exact lion’s mane mushroom dosage this would be beneficial for this nerve.

However, a dose of around 2000 mg per day should be enough to notice the beneficial effects of this mushroom on your nervous system. If you are new to lion’s mane, start with a lower dose and continue until you are satisfied with its results.

How much lion’s mane is in AdaptogenShroomsGranola?

AdaptogenShroomsgranola uses high-quality lion’s mane extracts made from whole grains medicinal mushrooms. Our double extraction method extracts both water-soluble beta-glucans and alcohol-soluble triterpenes. Our brewing process breaks down the indigestible chitin cell walls of the mushroom to extract far more of these compounds than conventional processes.

One serving of granola provides us with 250 mg of ultra-concentrated lion’s mane mushroom extract, which is eight times more concentrated than a regular lion’s mane mushroom supplement. So you’re getting as much potency as you would a 2000mg lion’s mane mushroom powder, all in a granola bowl.

Frequently asked questions about the lion’s mane and the vagus nerve

What supplements treat vagus nerve?

If you want to heal your vagus nerve, supplements containing adaptogens such as Hericium erinaceus, Lignosus rhinocerotisand Cordyceps militaris are a safe choice. Supplements containing choline, B12, and magnesium can also help the vagus nerve heal.

Does lion’s mane affect GABA?

Lion’s mane can stabilize GABA levels in the brain thanks to its beneficial effects on neurotransmitter production. GABA is the main inhibitory neurotransmitter in the brain, and low levels of GABA have been associated with increased levels of anxiety and stress.

How can I fix my vagus nerve naturally?

There are many ways to influence your vagus nerve towards health, but you have to be persistent to see improvement. Some people use adaptogens or herbal remedies such as chamomile tea and matcha.

Others use foods like spinach, nuts, seeds and bananas also help restore the vagus nerve. Many have found benefits in meditation practices. Here is a list of common ways people work on improving their vagus naturally.

  1. Deep breath. Practice slow, deep breaths to activate the vagus and promote relaxation.
  2. Exposure to cold. Embrace the cool! Taking a cold shower, splashing cold water, or even splashing ice water on your face can enhance the function of the vagus nerve.
  3. Gargle. A daily gargling session engages the throat muscles, which in turn stimulate the vagus.
  4. Song or hum. Serenate your VN by singing, humming or chanting to activate its functions.
  5. Probiotics. Feed your gut with probiotics found in fermented foods like yogurt and sauerkraut to support VN function.
  6. Omega-3 fatty acids. Eat fish like salmon and plant sources like walnuts and flaxseeds for VN-boosting omega-3 fatty acids.
  7. Socialization. Engage in positive social interactions, which activate the vagus nerve and improve overall well-being.
  8. Yoga and meditation. Do yoga and meditation to calm the sympathetic nervous system and bring the parasympathetic nervous system more online.
  9. Nutrients and adaptogens. Include nutrients such as B vitamins and magnesium in your diet, as they play a role in nerve function. Adaptogens such as Cordyceps, ashwagandha, lion’s mane, and Rhodiola rosea may also support the vagus nerve by helping your body adapt to stress.

By incorporating these methods into your daily routine, you’ll be on your way to improving your vagus nerve function naturally. Enjoy the journey as you hum a tune, socialize with friends, and savor nutrient-dense foods that support your parasympathetic nervous system.

What is the best vitamin for the vagus nerve?

Vitamin C is quite beneficial for the entire autonomic nervous system, including the vagus nerve. This nerve can also benefit from the use of choline, vitamin B-12, magnesium and calcium.

Does lion’s mane increase cortisol?

No, lion’s mane does not increase the stress response hormone, cortisol. On the contrary, research seems to suggest so lion’s mane reduces cortisol levels in those with high cortisol levels. For example, a Study 2022 found that increasing Hericium erinaceus intake directly correlated with decreasing plasma cortisol levels.

Is it bad to get a lion’s mane every day?

No, it’s not bad to take the lion’s mane every day. Taking lion’s mane supplements on a daily basis is not only safe but extremely beneficial. Even in high doses every day, lion’s mane has no serious adverse effects. However, we recommend starting with a lower dose if you are new to adaptogens, as lion’s mane can cause temporary digestive discomfort.

What calms the vagus nerve?

There are many ways to calm the vagus nerve, including immersing the face in cold water, deep breathing, and even singing loudly. When it comes to supplements, dietary supplements containing lion’s mane, valerian root and L-theanine is always a good choice, as all three stimulate the production of GABA, which calms the vagus nerve.

Should I take the lion’s mane at night or in the morning?

The ideal times to take lion’s mane supplements are in the morning and early afternoon. This adaptogenic mushroom can stimulate the brain and memory enhancement, so downloading it before starting your work day can be beneficial. If you take lion’s mane mushrooms late in the day, their stimulating effects may disturb your sleep and cause restlessness.

Is lion’s mane a stimulant?

Although lion’s mane is not a stimulant, it can have stimulating effects on the brain. This functional mushroom appears to increase cognitive abilities (especially focus and memory) and may even relieve the symptoms of ADHD. But unlike coffee and other stimulants, it doesn’t cause jitters or a midday energy slump.

What are the spiritual benefits of lion’s mane?

Lion’s mane mushrooms appear to have numerous spiritual benefits. These mushrooms improve brain health, reduce depression and anxiety, and reduce brain fog. In ancient China, Shaolin monks used lion’s mane mushroom in their daily practice to enhance their focus. They believed it strengthened their ‘Qi’, a supernatural, energizing life force.

Is lion’s mane good for diabetes?

Yes, the lion’s mane is one of the the best mushrooms for diabetes. This medicinal mushroom appears to lower blood glucose levels, help prevent diabetes, and relieve symptoms of diabetes, such as diabetic neuropathy.

Its effects Hericium erinaceus on blood sugar levels examined in a recent study. The studyconducted on diabetic rats, concluded that lion’s mane significantly reduced blood glucose levels and could be a powerful agent in the prevention and treatment of diabetes.

To learn more about the benefits of this fungus in diabetes, take a look our article on how diabetics can benefit from using lion’s mane.


  1. Wong, KH (2009). Improvement of functional recovery after rodent peroneal nerve injury by the lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae). International Journal of Medicinal Mushrooms, 11(3), 225–236.
  2. Kah-Hui Wong, Murali Naidu, Pamela David., Robiah Bakar, & Vikineswary, Sabaratnam (2012). Neuroregenerative potential of the lion’s mane mushroom, Hericium erinaceus (Bul.: Fr.) Pers. (Higher Basidiomycetes), in the Treatment of Peripheral Nerve Injury (Review). Int. Journal of Med. Mushrooms, 14(5), 427–446.
  3. Phan, CW (2014). Hericium erinaceus (Bull.: Fr) Pers. cultured under tropical conditions: isolation of erikenones and demonstration of NGF-induced neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. Food Funct., 5(12), 3160–3169.
  4. Martínez‐Mármol, R. (2023). Hericerin derivatives activate a pan-neurotrophic pathway in central hippocampal neurons that converges on ERK1/2 signaling that enhances spatial memory. Journal of Neurochemistry.
  5. Han, Y. (2022). Vagus nerve and underlying impact on the gut-brain microbiota axis in behaviors and neurodegenerative diseases. Journal of Inflammation Research, Volume 15, 6213–6230.
  6. Dilling, C. (2017). Hericium erinaceus extracts relieve inflammatory bowel disease by regulating immunity and gut microflora. Oncotarget, 8(49), 85838–85857.
  7. Seow, SLS (2015). Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor through the MEK/ERK1/2 signaling pathway in PC-12 cells. Scientific Reports, 5(1).
  8. Piccirillo, G. (2003). Effect of Vitamin C on Baroreflex Sensitivity in Chronic Heart Failure. Hypertension, 41(6), 1240-1245.
  9. Khieokhajonkhet, A. (2022). Effects of dietary Hericium erinaceus powder on growth, hematology, disease resistance, and gene-related immune response expression against heat challenge of Nile tilapia (Oreochromis niloticus). Animal Feed Science and Technology, 290, 115342.
  10. Liang, B. (2013). Antihyperglycemic and antihyperlipidemic activity of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complementary and Alternative Medicine, 13(1).

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